Evidence map›Paper›PMID 34684632›Full record

ArticleNutrients2021

Persistent Effect of Advanced Glycated Albumin Driving Inflammation and Disturbances in Cholesterol Efflux in Macrophages.

Carlos André Minanni, Adriana Machado-Lima, Rodrigo Tallada Iborra, Lígia Shimabukuro Okuda, Raphael de Souza Pinto, Monique de Fátima Mello Santana, Aécio Lopes de Araújo Lira, Edna Regina Nakandakare, Maria Lúcia Cardillo Côrrea-Giannella, Marisa Passarelli

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Carlos André MinanniLaboratório de Lípides (LIM-10), Hospital das Clínicas (HCFMUSP) da Faculdade de Medicina da Universidade de São Paulo, São Paulo 01246-000, Brazil.ORCID 0000-0003-3888-9979
Adriana Machado-LimaLaboratório de Lípides (LIM-10), Hospital das Clínicas (HCFMUSP) da Faculdade de Medicina da Universidade de São Paulo, São Paulo 01246-000, Brazil.ORCID 0000-0002-5741-3418
Rodrigo Tallada IborraLaboratório de Lípides (LIM-10), Hospital das Clínicas (HCFMUSP) da Faculdade de Medicina da Universidade de São Paulo, São Paulo 01246-000, Brazil.
Lígia Shimabukuro OkudaLaboratório de Lípides (LIM-10), Hospital das Clínicas (HCFMUSP) da Faculdade de Medicina da Universidade de São Paulo, São Paulo 01246-000, Brazil.
Raphael de Souza PintoLaboratório de Lípides (LIM-10), Hospital das Clínicas (HCFMUSP) da Faculdade de Medicina da Universidade de São Paulo, São Paulo 01246-000, Brazil.ORCID 0000-0002-2633-651X
Monique de Fátima Mello SantanaLaboratório de Lípides (LIM-10), Hospital das Clínicas (HCFMUSP) da Faculdade de Medicina da Universidade de São Paulo, São Paulo 01246-000, Brazil.ORCID 0000-0002-7380-0696
Aécio Lopes de Araújo LiraLaboratório de Lípides (LIM-10), Hospital das Clínicas (HCFMUSP) da Faculdade de Medicina da Universidade de São Paulo, São Paulo 01246-000, Brazil.ORCID 0000-0002-9654-9828
Edna Regina NakandakareLaboratório de Lípides (LIM-10), Hospital das Clínicas (HCFMUSP) da Faculdade de Medicina da Universidade de São Paulo, São Paulo 01246-000, Brazil.
Maria Lúcia Cardillo Côrrea-GiannellaLaboratório de Carboidratos e Radioimunoensaio (LIM-18), Hospital das Clínicas (HCFMUSP) da Faculdade de Medicina da Universidade de São Paulo, São Paulo 01246-000, Brazil.ORCID 0000-0003-3655-4446
Marisa PassarelliLaboratório de Lípides (LIM-10), Hospital das Clínicas (HCFMUSP) da Faculdade de Medicina da Universidade de São Paulo, São Paulo 01246-000, Brazil.ORCID 0000-0002-9249-4698
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRHospital Israelita Albert Einstein · BRUniversidade Nove de Julho · BR

Funding

São Paulo Research Foundation 2012/12088-7São Paulo Research Foundation 2012/19112-0São Paulo Research Foundation 2015/21072-5São Paulo Research Foundation 2016/15603-0
6 · The paper itself

Abstract

Advanced glycated albumin (AGE-albumin) impairs cholesterol efflux and contributes to inflammation in macrophages. The current study evaluated: (1) the persistence of the deleterious effect of AGE-albumin in cholesterol efflux and in inflammation, and (2) how metabolic control in diabetes mellitus (DM) contributes to attenuate the deleterious role of AGE-albumin in macrophage cholesterol homeostasis. Methods: AGE-albumin was produced in vitro or isolated from uncontrolled DM subjects' serum before (bGC) and after improved glycemic control (aGC). Albumin samples were incubated with bone marrow-derived macrophages and

Indexed as

ATP Binding Cassette Transporter 1Biological TransportCell Culture TechniquesCholesterolCytokinesDiabetes MellitusGlycated Serum AlbuminGlycation End Products, AdvancedGlycemic ControlHomeostasisHumansInflammationMacrophagesMembrane LipidsSerum AlbuminABCA1 protein, humanATP Binding Cassette Transporter 1CholesterolCytokinesGlycated Serum AlbuminGlycation End Products, AdvancedMembrane LipidsSerum AlbuminABCA-1advanced glycated albuminatherosclerosischolesterol effluxdiabetes mellitusinflammation

Identifiers

PMID34684632
PMCPMC8537611
OpenAlexW3206146090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.