Evidence map›Paper›PMID 34684612›Full record

ReviewNutrients2021

Skin Manifestations and Coeliac Disease in Paediatric Population.

Flavia Persechino, Gloria Galli, Severino Persechino, Francesco Valitutti, Letizia Zenzeri, Angela Mauro, Vito Domenico Corleto, Pasquale Parisi, Chiara Ziparo, Melania Evangelisti and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Gut-skin axis: Emerging insights for gastroenterologists-a narrative review.World journal of gastrointestinal pathophysiology · 2025
    Review
  4. Review
  5. Review
  6. Celiac Disease and Skin Diseases: A Bidirectional Mendelian Randomization Study.Clinical, cosmetic and investigational dermatology · 2025
    Article
  7. Review
  8. Feasibility of repairing skin defects by VEGFJournal of cellular and molecular medicine · 2023
    Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Who to screen and how to screen for celiac disease.World journal of gastroenterology · 2022
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Flavia PersechinoDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Gloria GalliDepartment of Medical-Surgical and Translational Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, 00185 Rome, Italy.
Severino PersechinoDermatology Unit, NESMOS Department, Faculty of Medicine & Psychology, Sapienza University of Rome, Sant'Andrea University Hospital, 00185 Rome, Italy.
Francesco ValituttiPediatric Unit, AOU San Giovanni di Dio e Ruggi D'Aragona, Salerno, Italy and EBRIS (European Biomedical Research Institute of Salerno), 84121 Salerno, Italy.ORCID 0000-0002-1473-2240
Letizia ZenzeriPediatric Emergency Unit, Emergency Pediatric Department, AORN Santobono-Pausilipon Children's Hospital, 80129 Naples, Italy.ORCID 0000-0001-5220-680X
Angela MauroPediatric Emergency Unit, Emergency Pediatric Department, AORN Santobono-Pausilipon Children's Hospital, 80129 Naples, Italy.ORCID 0000-0002-7008-3409
Vito Domenico CorletoDepartment of Medical-Surgical and Translational Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, 00185 Rome, Italy.
Pasquale ParisiPediatric Unit, NESMOS Department, Faculty of Medicine & Psychology, Sapienza University of Rome, Sant'Andrea University Hospital, 00185 Rome, Italy.ORCID 0000-0001-9042-8120
Chiara ZiparoPediatric Unit, NESMOS Department, Faculty of Medicine & Psychology, Sapienza University of Rome, Sant'Andrea University Hospital, 00185 Rome, Italy.
Melania EvangelistiPediatric Unit, NESMOS Department, Faculty of Medicine & Psychology, Sapienza University of Rome, Sant'Andrea University Hospital, 00185 Rome, Italy.
Giovanna QuatralePediatric Unit, NESMOS Department, Faculty of Medicine & Psychology, Sapienza University of Rome, Sant'Andrea University Hospital, 00185 Rome, Italy.
Giovanni Di NardoPediatric Unit, NESMOS Department, Faculty of Medicine & Psychology, Sapienza University of Rome, Sant'Andrea University Hospital, 00185 Rome, Italy.
Sapienza University of Rome · ITSantobono Children's Hospital · ITAzienda Ospedaliera Sant'Andrea · ITEuropean Biomedical Research Institute of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Celiac disease (CD) is an immune-mediated enteropathy caused by gluten ingestion, affecting approximately 1% of the worldwide population. Extraintestinal symptoms may be present as the first signs of CD, years before the CD diagnosis is made. A great variety of extraintestinal manifestations may be associated with CD. Cutaneous manifestations represent the main extraintestinal manifestations, with dermatitis herpetiformis being the most common in patients with CD. In adults, it has been demonstrated that the role of a gluten-free diet is crucial not only for the recovery of signs and symptoms associated with CD but also for cutaneous manifestations, which often improve after gluten avoidance. In children with CD, the association with skin disorders is well documented regarding dermatitis herpetiformis, but studies considering other dermatological conditions, such as psoriasis and atopic dermatitis, are few. The prevalence and manifestations of dermatological disorders in celiac children are often different from those in adults, explaining the gap between these populations. In addition, the therapeutic role of a gluten-free diet in the improvement in skin alterations is not fully understood in children and in adult population except for dermatitis herpetiformis. Therefore, cutaneous CD symptoms need to be known and recognized by physicians despite their specialties to improve early CD diagnosis, which is critical for a better prognosis. This review describes the current scientific evidence on skin manifestations associated with CD in the pediatric population.

Indexed as

Celiac DiseaseChildHumansSkinSkin Diseaseschildrencoeliac diseaseskin manifestation

Identifiers

PMID34684612
PMCPMC8537533
OpenAlexW3206749618

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.