ArticleNutrients2021
Untargeted Metabolomic Analysis of Human Milk from Mothers of Preterm Infants.
Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Automated, targeted, NMR spectral profiling of human breast milk.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Targeted metabolomics of organic and amino acids in giraffe milk during mid- to late-lactation.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Article
- Evaluating Metabolic Profiling of Human Milk Using Biocrates MxPMetabolites · 2025Article
- Untargeted metabolomics analysis of glycerophospholipid metabolism in very low birth weight infants administered multiple oil lipid emulsions.BMC pediatrics · 2024Article
- Non-Targeted Metabolomics of White Rhinoceros Colostrum and Its Changes During Early Lactation byMetabolites · 2024Article
- Comparison of canine colostrum and milk using a multi-omics approach.Animal microbiome · 2024Article
- African Elephant Milk Short Saccharide and Metabolite Composition and Their Changes over Lactation.Animals : an open access journal from MDPI · 2023Article
- Shaping infant development from the inside out: Bioactive factors in human milk.Seminars in perinatology · 2023Review
- Revisiting One-Carbon Metabolites in Human Breast Milk: Focus on S-Adenosylmethionine.Nutrients · 2023Article
- The metabolome of human milk is altered differentially by Holder pasteurization and high hydrostatic pressure processing.Frontiers in nutrition · 2023Article
- NMR Metabonomic Profile of Preterm Human Milk in the First Month of Lactation: From Extreme to Moderate Prematurity.Foods (Basel, Switzerland) · 2022Article
- Human milk microbiota: what did we learn in the last 20 years?Microbiome research reports · 2022Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The application of metabolomics in neonatology offers an approach to investigate the complex relationship between nutrition and infant health. Characterization of the metabolome of human milk enables an investigation into nutrients that affect the neonatal metabolism and identification of dietary interventions for infants at risk of diseases such as necrotizing enterocolitis (NEC). In this study, we aimed to identify differences in the metabolome of breast milk of 48 mothers with preterm infants with NEC and non-NEC healthy controls. A minimum significant difference was observed in the human milk metabolome between the mothers of infants with NEC and mothers of healthy control infants. However, significant differences in the metabolome related to fatty acid metabolism, oligosaccharides, amino sugars, amino acids, vitamins and oxidative stress-related metabolites were observed when comparing milk from mothers with control infants of ≤1.0 kg birth weight and >1.5 kg birth weight. Understanding the functional biological features of mothers' milk that may modulate infant health is important in the future of tailored nutrition and care of the preterm newborn.
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Registered trials
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