ArticleNutrients2021
Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study.
Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Effect of Cashew Nut Consumption on Biomarkers of Copper and Zinc Status in Adolescents with Obesity: A Randomized Controlled Trial.Nutrients · 2024Trial
- Association of Mixed Metal Exposures with Cardiovascular Disease: Insights from a Population-Based Study.Cardiovascular toxicology · 2026Article
- Article
- A Functional Shift of IGFBP3 in Osteoarthritis: From Cartilage Protection to Disease Promotion.Journal of inflammation research · 2026Review
- Cross-sectional associations between plasma copper, zinc and prediabetes among rural Indian adolescent girls: baseline data from the DERVAN cohort (DERVAN-8).Journal of biosciences · 2026Article
- Does the Relationship Between Microelements (Copper, Zinc and Selenium) and Proinflammatory Proteins (IL-6, IL-8 and Tissue Factor) Have Diagnostic Value in Equine Medicine?International journal of molecular sciences · 2025Article
- Personalized Nutrition in Pediatric Chronic Diseases.Metabolites · 2025Review
- The Biological Value of Proteins for Pediatric Growth and Development: A Narrative Review.Nutrients · 2025Review
- Method validation of an inductively coupled plasma mass spectrometry (ICP-MS) assay for the analysis of magnesium, copper and zinc in red blood cells.Journal of mass spectrometry and advances in the clinical lab · 2024Article
- Determination of trace elements and electrolyte levels in kidney tissue of simvastatin-treated septic rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Calcium, Phosphate, and Vitamin D in Children and Adolescents with Chronic Diseases: A Cross-Sectional Study.Nutrients · 2024Article
- Serum Copper/Zinc Ratio in Overweight and Obese Children: a Cross-Sectional Study.Biological trace element research · 2024Article
- Calcium, Phosphorus, and Vitamin D Levels in a Series of Cystic Fibrosis Patients: A Cross-Sectional Study.International journal of molecular sciences · 2024Article
- Nutritional Criminology: Why the Emerging Research on Ultra-Processed Food Matters to Health and Justice.International journal of environmental research and public health · 2024Article
- Investigation of Serum Pro-Inflammatory Markers and Trace Elements Among Short Stature in Eastern Uttar Pradesh and Bihar Populations.Journal of inflammation research · 2024Article
- The relationship between dietary patterns and blood mineral concentration among children in Hunan Province of China.BMC public health · 2023Article
- Evaluation of Selected Antioxidant Parameters in Ready-to-Eat Food for Infants and Young Children.Nutrients · 2023Article
- Copper/Zinc Ratio in Childhood and Adolescence: A Review.Metabolites · 2023Review
- Magnesium Status and Ca/Mg Ratios in a Series of Children and Adolescents with Chronic Diseases.Nutrients · 2022Article
- Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Copper is an essential micronutrient for humans. A cross-sectional and comparative study was done to assess serum Cu levels and serum copper/zinc (Cu/Zn) ratio and its association with nutritional indicators in a series of children and adolescents with chronic diseases. Anthropometric, biochemical, dietary, body composition, and bone densitometry assessments were carried out. Serum Cu and Zn were measured by atomic absorption spectrophotometry. Seventy-eight patients (55% women) participated. The mean serum Cu in the entire series and by nutritional status through body mass index (BMI) was normal. Serum Cu decreased significantly with age and was meaningfully higher in children than in adolescents. The risk of finding altered Cu levels in children and men was higher than in adolescents and women, respectively. Twenty-two per cent of patients had abnormal serum copper levels, 13 had hypercupremia, and four had hypocupremia. The Cu/Zn ratio was greater than 1.00 for 87% of the patients, which is an indicator of an inflammatory state. All patients with hypozincemia and hypocupremia had deficient Zn intake, but only 65% of the patients with hypercupremia had dietary Zn deficiency. Consequently, the Cu/Zn ratio could indicate an inflammatory state and a high risk of zinc deficiency in this specific child population.
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