Evidence map›Paper›PMID 34684515›Full record

ArticleNutrients2021

Anti-Inflammatory Properties of Fructo-Oligosaccharides in a Calf Lung Infection Model and in

Yang Cai, Myrthe S Gilbert, Walter J J Gerrits, Gert Folkerts, Saskia Braber

Abstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yang CaiDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.ORCID 0000-0001-7700-9781
Myrthe S GilbertAnimal Nutrition Group, Wageningen University, 6708 WD Wageningen, The Netherlands.
Walter J J GerritsAnimal Nutrition Group, Wageningen University, 6708 WD Wageningen, The Netherlands.
Gert FolkertsDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.ORCID 0000-0003-0630-2192
Saskia BraberDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.

Funding

China Scholarship Council 201608320245Nederlandse Organisatie voor Wetenschappelijk Onderzoek ALWCC.2015.4
6 · The paper itself

Abstract

Emerging antimicrobial-resistant pathogens highlight the importance of developing novel interventions. Here, we investigated the anti-inflammatory properties of Fructo-oligosaccharides (FOS) in calf lung infections and in airway epithelial cells stimulated with pathogens, and/or bacterial components. During a natural exposure, 100 male calves were fed milk replacer with or without FOS for 8 weeks. Then, immune parameters and cytokine/chemokine levels in the bronchoalveolar lavage fluid (BALF) and blood were measured, and clinical scores were investigated. Calf primary bronchial epithelial cells (PBECs) and human airway epithelial cells (A549) were treated with

Indexed as

AnimalsAnti-Inflammatory AgentsCattleDisease Models, AnimalEpithelial CellsLungMannheimia haemolyticaOligosaccharidesPasteurella multocidaPneumonia of Calves, EnzooticAnti-Inflammatory AgentsfructooligosaccharideOligosaccharidesairway inflammationanimal modelnon-digestible oligosaccharidesnutritionpneumoniarespiratory diseases

Identifiers

PMID34684515
PMCPMC8537102

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.