Evidence map›Paper›PMID 34684508›Full record

Trial reportNutrients2021

Change in Micronutrient Intake among People with Relapsing-Remitting Multiple Sclerosis Adapting the Swank and Wahls Diets: An Analysis of Weighed Food Records.

Tyler J Titcomb, Lisa Brooks, Karen L Smith, Patrick Ten Eyck, Linda M Rubenstein, Terry L Wahls, Linda G Snetselaar

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Association of serum homocysteine, folate, and vitamin BMultiple sclerosis and related disorders · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tyler J TitcombDepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
Lisa BrooksDepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
Karen L SmithDepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
Patrick Ten EyckInstitute for Clinical and Translational Science, University of Iowa, Iowa City, IA 52242, USA.
Linda M RubensteinDepartment of Epidemiology, University of Iowa, Iowa City, IA 52242, USA.
Terry L WahlsDepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-6059-7994
Linda G SnetselaarDepartment of Epidemiology, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-6615-0779
University of Iowa · US

Funding

The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
Diabetes Research Training Program Diversity SupplementT32DK112751 · NIDDK · UNIVERSITY OF IOWA · PI Andrew W Norris · 2017 to 2026
$4.8M
National Multiple Sclerosis Society RG-1506-04312NIDDK NIH HHS T32 DK112751NIDDK NIH HHS T32DK112751-01NIH HHS UL1TR002537
6 · The paper itself

Abstract

The low-saturated fat (Swank) and modified Paleolithic elimination (Wahls) diets have shown promise for MS symptoms; however, due to their restriction of specific foods, inadequate intake of micronutrients is concerning. Therefore, as part of a randomized trial, weighed food records were collected on three consecutive days and were used to evaluate the intake of micronutrients among people with relapsing remitting MS adapting these diets. After randomization to either the Swank or Wahls diets, diet education and support was provided by registered dietitians at baseline and throughout the first 12 weeks of the intervention. Usual intake of each micronutrient was estimated and then evaluated with the EAR-cut point method. At 12 weeks, the Swank group had significant reductions in the proportion with inadequate intake from food for vitamins C, D, and E, while the Wahls group had significant reductions for magnesium and vitamins A, C, D, and E. However, the proportion with inadequate intake significantly increased for calcium, thiamin, and vitamin B

Indexed as

Diet RecordsEatingAdultDiet, Fat-RestrictedDiet, PaleolithicFatigueFemaleHumansMaleMiddle AgedMultiple Sclerosis, Relapsing-RemittingQuality of LifeSingle-Blind MethodTreatment Outcomelow-saturated fat dietmicronutrient inadequacymicronutrientsmodified Paleolithic dietmultiple sclerosis

Identifiers

PMID34684508
PMCPMC8540533
OpenAlexW3206403691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.