Evidence map›Paper›PMID 34684482›Full record

ReviewNutrients2021

Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin.

Clayton Vasey, Jennifer McBride, Kayla Penta

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

172 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Food Intake According to Clock Gene Polymorphisms: A Systematic Review.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Pooled it
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  9. Trial
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  13. Review
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  15. Article
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  17. Article
  18. The interplay of circadian rhythms and cancer pain: a narrative review.Journal of anesthesia, analgesia and critical care · 2026
    Review
  19. Article
  20. Social Rhythms, Depressive Symptoms, and Quality of Life: An Unbreakable Bond in an Older Adult Sample.International journal of environmental research and public health · 2026
    Observational

112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Clayton VaseySchool of Pharmacy, College of Medicine, Lake Erie College of Osteopathic Medicine, Erie, PA 16509, USA.
Jennifer McBrideCOVID/Communicable Disease, Cabarrus Health Alliance, Kannapolis, NC 28081, USA.
Kayla PentaCollege of Medicine, Lake Erie College of Osteopathic Medicine, Elmira, NY 14901, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sleep is an essential component of overall human health but is so tightly regulated that when disrupted can cause or worsen certain ailments. An important part of this process is the presence of the well-known hormone, melatonin. This compound assists in the governing of sleep and circadian rhythms. Previous studies have postulated that dysregulation of melatonin rhythms is the driving force behind sleep and circadian disorders. A computer-aided search spanning the years of 2015-2020 using the search terms melatonin, circadian rhythm, disorder yielded 52 full text articles that were analyzed. We explored the mechanisms behind melatonin dysregulation and how it affects various disorders. Additionally, we examined associated therapeutic treatments including bright light therapy (BLT) and exogenous forms of melatonin. We found that over the past 5 years, melatonin has not been widely investigated in clinical studies thus there remains large gaps in its potential utilization as a therapy.

Indexed as

AnimalsBiosynthetic PathwaysCircadian RhythmHumansLightMelatoninTranscription, GeneticMelatoninbright light therapycircadian rhythmdelayed sleep phase disordermelatoninsleep

Identifiers

PMID34684482
PMCPMC8538349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.