Evidence map›Paper›PMID 34684459›Full record

ArticleNutrients2021

A Six-Day, Lifestyle-Based Immersion Program Mitigates Cardiovascular Risk Factors and Induces Shifts in Gut Microbiota, Specifically

Angelica P Ahrens, Tyler Culpepper, Brittany Saldivar, Stephen Anton, Scott Stoll, Eileen M Handberg, Ke Xu, Carl Pepine, Eric W Triplett, Monica Aggarwal

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 4 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
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  12. Frontiers in microbiology · 2026
    Article
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  16. ButyrylatedActa pharmaceutica Sinica. B · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Angelica P AhrensDepartment of Microbiology and Cell Science, College of Agricultural and Life Sciences, University of Florida, 1355 Museum Dr, Gainesville, FL 32603, USA.
Tyler CulpepperDepartment of Medicine, College of Medicine, University of Florida, P.O. Box 100277, Gainesville, FL 32610, USA.ORCID 0000-0002-8298-9259
Brittany SaldivarDepartment of Medicine, College of Medicine, University of Florida, P.O. Box 100277, Gainesville, FL 32610, USA.
Stephen AntonDepartment of Aging and Geriatric Research, University of Florida, 210 E. Mowry Rd, Gainesville, FL 32611, USA.
Scott StollTotal Health Immersions, P.O. Box 741596, Boynton Beach, FL 33474, USA.
Eileen M HandbergDivision of Cardiovascular Medicine, Department of Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, USA.
Ke XuDepartment of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, 2004 Mowry Rd, Gainesville, FL 32610, USA.ORCID 0000-0002-6153-5055
Carl PepineDivision of Cardiovascular Medicine, Department of Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, USA.ORCID 0000-0002-6011-681X
Eric W TriplettDepartment of Microbiology and Cell Science, College of Agricultural and Life Sciences, University of Florida, 1355 Museum Dr, Gainesville, FL 32603, USA.
Monica AggarwalDivision of Cardiovascular Medicine, Department of Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, USA.
University of Florida · USFlorida Museum of Natural History · USImmersion (United States) · US

Funding

Whole Foods, Inc. N/A
6 · The paper itself

Abstract

Cardiovascular disease (CVD) prevalence remains elevated globally. We have previously shown that a one-week lifestyle "immersion program" leads to clinical improvements and sustained improvements in quality of life in moderate to high atherosclerotic CVD (ASCVD) risk individuals. In a subsequent year of this similarly modeled immersion program, we again collected markers of cardiovascular health and, additionally, evaluated intestinal microbiome composition. ASCVD risk volunteers (

Indexed as

DietGastrointestinal MicrobiomeHeart Disease Risk FactorsLife StyleAdultBiodiversityBiomarkersBody Weights and MeasuresDisease SusceptibilityFaecalibacterium prausnitziiFecesFemaleHumansMaleMetagenomicsMiddle AgedBiomarkerscardiovascular diseasecholesterolhsCRPhypertensioninflammationlifestylemicrobiomeplant based dietTMAOwhole food

Identifiers

PMID34684459
PMCPMC8539164
OpenAlexW3203431758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.