SynthesisNutrients2021
The Relation between Caffeine Consumption and Endometriosis: An Updated Systematic Review and Meta-Analysis.
Synthesis in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Review
- Causal relationship between diet and common female diseases: a comprehensive Mendelian randomization study.BMC women's health · 2025Article
- The Role of Nutrition in Endometriosis Prevention and Management: A Comprehensive Review.International journal of fertility & sterility · 2025Review
- Diet and Endometriosis: An Umbrella Review.Foods (Basel, Switzerland) · 2025Review
- Endometriosis and Nutrition: Therapeutic Perspectives.Journal of clinical medicine · 2025Review
- Causal analysis of dietary preferences and the risk of endometriosis using large-scale population data.Scientific reports · 2025Article
- Association between pro-inflammatory diet and fecal incontinence: a large population-based study.Frontiers in nutrition · 2025Article
- Deleterious Effects of Caffeine Consumption on Reproductive Functions of Female Wistar Rats.JBRA assisted reproduction · 2024Article
- Endometriosis: A Comprehensive Analysis of the Pathophysiology, Treatment, and Nutritional Aspects, and Its Repercussions on the Quality of Life of Patients.Biomedicines · 2024Review
- Common Beverage Consumption and Benign Gynecological Conditions.Beverages (Basel, Switzerland) · 2024Article
- Diet in Prevention and Treatment of Endometriosis: Current State of Knowledge.Current nutrition reports · 2024Review
- The Main Theories on the Pathogenesis of Endometriosis.International journal of molecular sciences · 2023Review
- I Am the 1 in 10-What Should I Eat? A Research Review of Nutrition in Endometriosis.Nutrients · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the contributing factors leading to endometriosis remain unclear, its clinical heterogeneity suggests a multifactorial causal background. Amongst others, caffeine has been studied extensively during the last decade as a putative contributing factor. In this systematic review and meta-analysis, we provide an overview/critical appraisal of studies that report on the association between caffeine consumption and the presence of endometriosis. In our search strategy, we screened PubMed and Scopus for human studies examining the above association. The main outcome was the relative risk of endometriosis in caffeine users versus women consuming little or no caffeine (<100 mg/day). Subgroup analyses were conducted for different levels of caffeine intake: high (>300 mg/day) or moderate (100-300 mg/day). Ten studies were included in the meta-analysis (five cohort and five case-control studies). No statistically significant association was observed between overall caffeine consumption and risk for endometriosis (RR 1.12, 95% confidence interval (CI) 0.97-1.28, I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.