Evidence map›Paper›PMID 34684453›Full record

ReviewNutrients2021

Alcohol's Impact on the Fetus.

Svetlana Popova, Danijela Dozet, Kevin Shield, Jürgen Rehm, Larry Burd

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07456579 (Assessment of Alcohol and Cannabis Use Among Pregnant Women in Slovenia and Meconium Microbiome Analysis of Positive Samples), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07456579 enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Assessment of Alcohol and Cannabis Use Among Pregnant Women in Slovenia and Meconium Microbiome Analysis of Positive Samples

TypeobservationalSponsorUniversity Medical Centre LjubljanaRan2024 to 2026Enrolled600ConditionsMicrobiome Analysis, Drug Abuse in Pregnancy, Alcohol Abuse in Pregnancy, Health Behavior, Risky
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
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  5. Article
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  7. Article
  8. Article
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  12. Review
  13. Prenatal Alcohol Exposure and Mitochondrial Function in the Brain.Advances in experimental medicine and biology · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Health Promotion and Support Grounded in Interconnected Influences on Alcohol Use in Pregnancy.International journal of environmental research and public health · 2025
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 4 countries.

Svetlana PopovaInstitute for Mental Health Policy Research, Centre for Addiction and Mental Health, 33 Ursula Franklin Street, Toronto, ON M5S 2S1, Canada.ORCID 0000-0002-6308-1157
Danijela DozetInstitute for Mental Health Policy Research, Centre for Addiction and Mental Health, 33 Ursula Franklin Street, Toronto, ON M5S 2S1, Canada.
Kevin ShieldInstitute for Mental Health Policy Research, Centre for Addiction and Mental Health, 33 Ursula Franklin Street, Toronto, ON M5S 2S1, Canada.
Jürgen RehmInstitute for Mental Health Policy Research, Centre for Addiction and Mental Health, 33 Ursula Franklin Street, Toronto, ON M5S 2S1, Canada.ORCID 0000-0001-5665-0385
Larry BurdDepartment of Pediatrics, University of North Dakota School of Medicine and Health Sciences, 1301 N Columbia Rd., Grand Forks, ND 58202, USA.
Centre for Addiction and Mental Health · CAUniversity of North Dakota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlcohol is a teratogen and prenatal exposure may adversely impact the developing fetus, increasing risk for negative outcomes, including Fetal Alcohol Spectrum Disorder (FASD). Global trends of increasing alcohol use among women of childbearing age due to economic development, changing gender roles, increased availability of alcohol, peer pressure and social acceptability of women's alcohol use may put an increasing number of pregnancies at risk for prenatal alcohol exposure (PAE). This risk has been exacerbated by the ongoing COVID-19 pandemic in some countries.

methodThis literature review presents an overview on the epidemiology of alcohol use among childbearing age and pregnant women and FASD by World Health Organization regions; impact of PAE on fetal health, including FASD; associated comorbidities; and social outcomes. RESULTS/

conclusionThe impact of alcohol on fetal health and social outcomes later in life is enormous, placing a huge economic burden on countries. Prevention of prenatal alcohol exposure and early identification of affected individuals should be a global public health priority.

Indexed as

Alcohol DrinkingCausalityEthanolFemaleFetal Alcohol Spectrum DisordersHumansPregnancyPrenatal Exposure Delayed EffectsEthanolalcoholfetalfetal alcohol spectrum disordermorbiditymortalitypregnancy

Identifiers

PMID34684453
PMCPMC8541151
OpenAlexW3204333919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.