Evidence map›Paper›PMID 34684436›Full record

ArticleNutrients2021

Maturation of the Visceral (Gut-Adipose-Liver) Network in Response to the Weaning Reaction versus Adult Age and Impact of Maternal High-Fat Diet.

Maria Angela Guzzardi, Federica La Rosa, Daniela Campani, Andrea Cacciato Insilla, Vincenzo De Sena, Daniele Panetta, Maurizia Rossana Brunetto, Ferruccio Bonino, Maria Carmen Collado, Patricia Iozzo

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Maria Angela GuzzardiInstitute of Clinical Physiology, National Research Council (CNR), 56124 Pisa, Italy.ORCID 0000-0001-9574-5088
Federica La RosaInstitute of Clinical Physiology, National Research Council (CNR), 56124 Pisa, Italy.ORCID 0000-0003-1671-6057
Daniela CampaniDepartment of Surgical, Medical, Molecular Pathology and Critical Care Medicine, Division of Pathology, Pisa University Hospital, 56124 Pisa, Italy.ORCID 0000-0001-5987-734X
Andrea Cacciato InsillaDepartment of Surgical, Medical, Molecular Pathology and Critical Care Medicine, Division of Pathology, Pisa University Hospital, 56124 Pisa, Italy.
Vincenzo De SenaInstitute of Clinical Physiology, National Research Council (CNR), 56124 Pisa, Italy.
Daniele PanettaInstitute of Clinical Physiology, National Research Council (CNR), 56124 Pisa, Italy.ORCID 0000-0002-4184-0175
Maurizia Rossana BrunettoDepartment of Clinical and Experimental Medicine, University of Pisa, 56124 Pisa, Italy.ORCID 0000-0001-8364-9152
Ferruccio BoninoInstitute of Biostructure and Bioimaging (IBB), National Research Council (CNR), 80145 Napoli, Italy.ORCID 0000-0001-9942-0328
Maria Carmen ColladoInstitute of Agrochemistry and Food Technology-National Research Council (IATA-CSIC), 46980 Valencia, Spain.ORCID 0000-0002-6204-4864
Patricia IozzoInstitute of Clinical Physiology, National Research Council (CNR), 56124 Pisa, Italy.
Istituto di Fisiologia Clinica · ITAzienda Ospedaliera Universitaria Pisana · ITInstitute of Biostructure and Bioimaging · ITInstituto de Agroquímica y Tecnología de Alimentos · ESUniversity of Pisa · IT

Funding

Joint Programming Initiative A healthy diet for a healthy life INTIMIC 085 GUTMOMJoint Programming Initiative A healthy diet for a healthy life Knowledge Platform, KP-778 MISVILUPPOMinistero dell'Istruzione, dell'Università e della Ricerca CNR Flagship Project InterOmics
6 · The paper itself

Abstract

Metabolic-associated fatty liver disease is a major cause of chronic pathologies, of which maternal obesity is a frequent risk factor. Gut wall and microbiota, visceral fat, and liver form a pre-systemic network for substrates and pro-inflammatory factors entering the body, undergoing accelerated maturation in early-life when the weaning reaction, i.e., a transitory inflammatory condition, affects lifelong health. We aimed to characterize organ metabolism in the above network, in relation to weaning reaction and maternal obesity. Weaning or 6-months-old offspring of high-fat-diet and normal-diet fed dams underwent in vivo imaging of pre-/post-systemic glucose uptake and tissue radiodensity in the liver, visceral fat, and intestine, a liver histology, and microbiota and metabolic pathway analyses. Weaning mice showed the dominance of gut

Indexed as

Diet, High-FatFeedback, PhysiologicalMaternal Nutritional Physiological PhenomenaPrenatal Exposure Delayed EffectsWeaningAdipose TissueAge FactorsAnimalsBiomarkersDisease SusceptibilityEnergy MetabolismFemaleGastrointestinal MicrobiomeGastrointestinal TractImmunohistochemistryLiverBiomarkerscomputerized tomographyglucose metabolismgut microbiotainflammationKEGG pathwaysliver steatohepatitismaternal obesitypositron emission tomographyTNF-alphaweaning reaction

Identifiers

PMID34684436
PMCPMC8541006
OpenAlexW3203072208

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.