Evidence map›Paper›PMID 34684433›Full record

ReviewNutrients2021

Iron Deficiency in Celiac Disease: Prevalence, Health Impact, and Clinical Management.

Miguel A Montoro-Huguet, Santos Santolaria-Piedrafita, Pablo Cañamares-Orbis, José Antonio García-Erce

3 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05172895 completednot on this map

Clinical Characteristics and Pathogenic Mechanisms of Anemia in Celiac Disease

TypeobservationalSponsorUniversity of PalermoRan2001 to 2021Enrolled159ConditionsCeliac DiseaseArmsPresence, prevalence, severity, and morphological characteristics of anemia, Effect of gluten-free diet on anemia
NCT06742528 narecruitingnot on this mapstarted 2024, after this paper: background citation

Comparison Of Efficacy Of Iron Polymaltose Complex And Ferrous Sulphate In Iron Deficiency Anemia In Pediatric Patients With Iron Deficiency Anemia

TypeinterventionalSponsorArooj KhanRan2024 to 2025Enrolled198ConditionsIron Deficiency Anemia, Iron Deficiency, Anaemia in ChildrenArmsFerrous sulfate, Iron Polymaltose Complex
NCT07563582 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Oral Sucrosomial Iron Supplementation in Children With Celiac Disease and Iron Deficiency or Anemia: a Double-blind, Randomized, Placebo-controlled Trial

TypeinterventionalSponsorIstituto Giannina GasliniRan2025 to 2027Enrolled60ConditionsCeliac Disease in Children, Anemia, Iron DeficienciesArmsSideral forte® VERUM drops, Sideral forte® matching PLACEBO drops
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Pediatric autoimmune gastritis: An international, multicentric study.Journal of pediatric gastroenterology and nutrition · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Molecular mechanisms of ferroptosis in cardiovascular disease.Molecular and cellular biochemistry · 2024
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Miguel A Montoro-HuguetDepartment of Medicine, Faculty of Health Sciences, University of Zaragoza, 22002 Huesca, Spain.ORCID 0000-0001-7676-9842
Santos Santolaria-PiedrafitaGastroenterology, Hepatology and Nutrition Unit, St George's Hospital, 20004 Huesca, Spain.
Pablo Cañamares-OrbisGastroenterology, Hepatology and Nutrition Unit, St George's Hospital, 20004 Huesca, Spain.
José Antonio García-ErceBlood and Tissue Bank of Navarra, Pamplona, 31008 Navarra, Spain.ORCID 0000-0001-7662-6286
Instituto de Investigación Sanitaria Aragón · ESNavarrabiomed · ESUniversidad de Zaragoza · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron is an essential nutrient to life and is required for erythropoiesis, oxidative, metabolism, and enzymatic activities. It is a cofactor for mitochondrial respiratory chain enzymes, the citric acid cycle, and DNA synthesis, and it promotes the growth of immune system cells. Thus, iron deficiency (ID) leads to deleterious effects on the overall health of individuals, causing significant morbidity. Iron deficiency anemia (IDA) is the most recognized type of anemia in patients with celiac disease (CD) and may be present in over half of patients at the time of diagnosis. Folate and vitamin B12 malabsorption, nutritional deficiencies, inflammation, blood loss, development of refractory CD, and concomitant

Indexed as

Age FactorsAnemia, Iron-DeficiencyBiomarkersCeliac DiseaseCombined Modality TherapyDisease ManagementDisease SusceptibilityFemaleHematologic TestsHumansIronOutcome Assessment, Health CarePregnancyPrevalenceRisk FactorsSymptom AssessmentBiomarkersIronceliac diseasegluten-free dietiron deficiencyiron deficiency anemiairon intravenousiron oralmalabsorptionmicronutrient deficienciespatient-blood management (PBM)

Identifiers

PMID34684433
PMCPMC8537360
OpenAlexW3203688704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.