Evidence map›Paper›PMID 34684431›Full record

ArticleNutrients2021

Hypocaloric Dieting Unsettles the Neuroenergetic Homeostasis in Humans.

Ewelina K Wardzinski, Carolin Hyzy, Kai Uwe Duysen, Uwe H Melchert, Kamila Jauch-Chara, Kerstin M Oltmanns

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ewelina K WardzinskiSection of Psychoneurobiology, Center of Brain, Behavior and Metabolism, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany.
Carolin HyzySection of Psychoneurobiology, Center of Brain, Behavior and Metabolism, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany.
Kai Uwe DuysenSection of Psychoneurobiology, Center of Brain, Behavior and Metabolism, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany.
Uwe H MelchertSection of Psychoneurobiology, Center of Brain, Behavior and Metabolism, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany.
Kamila Jauch-CharaSection of Psychoneurobiology, Center of Brain, Behavior and Metabolism, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany.
Kerstin M OltmannsSection of Psychoneurobiology, Center of Brain, Behavior and Metabolism, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany.
University of Lübeck · DE

Funding

Deutsche Forschungsgemeinschaft TRR-134
6 · The paper itself

Abstract

backgroundThe effects of low-calorie dieting in obesity are disappointing in the long run. The brain's energy homeostasis plays a key role in the regulation of body weight. We hypothesized that the cerebral energy status underlies an adaptation process upon body weight loss due to hypocaloric dieting in humans.

objectiveWe instructed 26 healthy obese participants to reduce body weight via replacement of meals by a commercial diet product for two weeks. The cerebral energy status was assessed by

resultsWeight loss induced a decline in blood concentrations of insulin (

conclusionLow-calorie dieting reduces neurohormonal stress axis activity and increases the neuroenergetic status in obesity. This effect was of a transient nature in terms of stress hormonal measures. In contrast, PCr/Pi ratios remained increased after dieting and at follow-up while NADH levels were still reduced, which indicates a persistently unsettled neuroenergetic homeostasis upon diet-induced rapid body weight loss.

Indexed as

Caloric RestrictionDiet, ReducingEnergy MetabolismHomeostasisNeurogenesisAdenosine TriphosphateBiomarkersBody CompositionBody WeightGlucoseHumansMagnetic Resonance SpectroscopyStress, PhysiologicalAdenosine TriphosphateBiomarkersGlucose31 phosphorus magnetic resonance spectroscopyadenosine triphosphatebody weightbrainhumanshypocaloric dietingobesityphosphocreatine

Identifiers

PMID34684431
PMCPMC8541113
OpenAlexW3202976600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.