Evidence map›Paper›PMID 34684410›Full record

ArticleNutrients2021

Nutritional Intake, White Matter Integrity, and Neurodevelopment in Extremely Preterm Born Infants.

Lisa M Hortensius, Els Janson, Pauline E van Beek, Floris Groenendaal, Nathalie H P Claessens, Henriette F N Swanenburg de Veye, Maria J C Eijsermans, Corine Koopman-Esseboom, Jeroen Dudink, Ruurd M van Elburg and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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  5. [Research hotspots in post-discharge follow-up management of preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Lisa M HortensiusDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The Netherlands.
Els JansonDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The Netherlands.ORCID 0000-0001-6372-0097
Pauline E van BeekDepartment of Neonatology, Máxima Medical Center, 5504 DB Veldhoven, The Netherlands.
Floris GroenendaalDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The Netherlands.ORCID 0000-0002-9284-1637
Nathalie H P ClaessensDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The Netherlands.
Henriette F N Swanenburg de VeyeDepartment of Medical Psychology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The Netherlands.
Maria J C EijsermansDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The Netherlands.
Corine Koopman-EsseboomDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The Netherlands.
Jeroen DudinkDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The Netherlands.
Ruurd M van ElburgDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The Netherlands.ORCID 0000-0003-0310-6540
Manon J N L BendersDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The Netherlands.ORCID 0000-0001-5491-9168
Maria Luisa TatarannoDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The Netherlands.
Niek E van der AaDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The Netherlands.
Utrecht University · NLRadboud University Nijmegen · NL

Funding

Athena grant, 'Utrecht Center for Food and Health - research program specialized nutrition', subsidy from the Dutch Ministry of Economic Affairs, Utrecht Province and the municipality of Utrecht. NA
6 · The paper itself

Abstract

backgroundDetermining optimal nutritional regimens in extremely preterm infants remains challenging. This study aimed to evaluate the effect of a new nutritional regimen and individual macronutrient intake on white matter integrity and neurodevelopmental outcome.

methodsTwo retrospective cohorts of extremely preterm infants (gestational age < 28 weeks) were included. Cohort B (

resultsCompared to cohort A, infants in cohort B had significantly higher protein intake (3.4 g/kg/day vs. 2.7 g/kg/day) and higher fractional anisotropy (FA) in several white matter tracts but lower motor scores at 2 years CA (mean (SD) 103 (12) vs. 109 (12)). Higher protein intake was associated with higher FA and lower motor scores at 2 years CA (B = -6.7,

conclusionIn extremely preterm born infants, postnatal protein intake seems important for white matter development but does not necessarily improve long-term cognitive and motor development.

Indexed as

CognitionDietEatingMotor SkillsAnisotropyDietary ProteinsDiffusion Tensor ImagingEnergy IntakeFemaleHumansInfant, Extremely PrematureInfant FormulaInfant, NewbornMaleRetrospective StudiesWhite MatterDietary Proteinsdiffusion tensor imagingextremely preterm infantneurodevelopmental outcomenutritionwhite matter

Identifiers

PMID34684410
PMCPMC8539908
OpenAlexW3204840469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.