Evidence map›Paper›PMID 34684382›Full record

ArticleNutrients2021

Association of Body Weight Variability with Adverse Cardiovascular Outcomes in Patients with Pre-Dialysis Chronic Kidney Disease.

Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Sue K Park, Yong-Soo Kim, Yeong Hoon Kim, Kyu Hun Choi, Kook-Hwan Oh and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sang Heon SuhDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, Korea.ORCID 0000-0003-3076-3466
Tae Ryom OhDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, Korea.
Hong Sang ChoiDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, Korea.ORCID 0000-0001-8191-4071
Chang Seong KimDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, Korea.ORCID 0000-0001-8753-7641
Eun Hui BaeDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, Korea.
Sue K ParkDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.ORCID 0000-0001-5002-9707
Yong-Soo KimDepartment of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul 06591, Korea.ORCID 0000-0003-2152-1289
Yeong Hoon KimDepartment of Internal Medicine, Busan Paik Hospital, College of Medicine, Inje University, Busan 47392, Korea.
Kyu Hun ChoiDepartment of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul 03722, Korea.
Kook-Hwan OhDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, Korea.ORCID 0000-0001-9525-2179
Seong Kwon MaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, Korea.
Soo Wan KimDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, Korea.ORCID 0000-0002-3540-9004
On Behalf Of The KoreaN Cohort Study For Outcomes In Patients With Chronic Kidney Disease Know-Ckd Investigators

Funding

Chonnam National University Hospital Biomedical Research Institute BCRI20062the Korea Health Technology R&D Project through the Korea Health Industry Development In-stitute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea HR20C0021the Research Program funded by the Korea Centers for Disease Control and Prevention 2011E3300300, 2012E3301100, 2013E3301600, 2013E3301601, 2013E3301602, 2016E3300200, 2016E3300201, 2016E3300202, and 2019E320100
6 · The paper itself

Abstract

To investigate the association of body weight variability (BWV) with adverse cardiovascular (CV) outcomes in patient with pre-dialysis chronic kidney disease (CKD), a total of 1867 participants with pre-dialysis CKD from Korean Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) were analyzed. BWV was defined as the average absolute difference between successive values. The primary outcome was a composite of non-fatal CV events and all-cause mortality. Secondary outcomes were fatal and non-fatal CV events and all-cause mortality. High BWV was associated with increased risk of the composite outcome (adjusted hazard ratio (HR) 1.745, 95% confidence interval (CI) 1.065 to 2.847) as well as fatal and non-fatal CV events (adjusted HR 1.845, 95% CI 1.136 to 2.996) and all-cause mortality (adjusted HR 1.861, 95% CI 1.101 to 3.145). High BWV was associated with increased risk of fatal and non-fatal CV events, even in subjects without significant body weight gain or loss during follow-up periods (adjusted HR 2.755, 95% CI 1.114 to 6.813). In conclusion, high BWV is associated with adverse CV outcomes in patients with pre-dialysis CKD.

Indexed as

Body WeightRenal DialysisCardiovascular DiseasesFemaleFollow-Up StudiesHumansKaplan-Meier EstimateMaleMiddle AgedProportional Hazards ModelsRenal Insufficiency, Chronicall-cause mortalitybody weight variabilitycardiovascular eventschronic kidney disease

Identifiers

PMID34684382
PMCPMC8539704

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.