Evidence map›Paper›PMID 34684321›Full record

ArticleNutrients2021

Low Serum 25-hydroxyvitamin D Level Does Not Adversely Affect Bone Turnover in Prepubertal Children.

Wojciech J Bilinski, Lukasz Szternel, Joanna Siodmiak, Przemyslaw T Paradowski, Krzysztof Domagalski, Grazyna Sypniewska

Abstract read
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In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wojciech J BilinskiDepartment of Orthopaedics, KoMed, Poddebice Health Center, 85067 Poddebice, Poland.
Lukasz SzternelDepartment of Laboratory Medicine, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, 87110 Torun, Poland.ORCID 0000-0003-1499-3675
Joanna SiodmiakDepartment of Laboratory Medicine, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, 87110 Torun, Poland.ORCID 0000-0002-7374-9122
Przemyslaw T ParadowskiDepartment of Surgical and Perioperative Sciences, Division of Orthopedics, Sunderby Research Unit, Umeå University, Sunderby Central Hospital of Norrbotten, 90187 Luleå, Sweden.
Krzysztof DomagalskiDepartment of Immunology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, 87110 Torun, Poland.ORCID 0000-0002-9766-8730
Grazyna SypniewskaDepartment of Laboratory Medicine, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, 87110 Torun, Poland.ORCID 0000-0003-1350-7073

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Both vitamin D and insulin-like growth factor 1 (IGF-1) play essential roles in bone metabolism and may interact during prepubertal bone accrual. We investigated the association of low serum 25-hydroxyvitamin D (25(OH)D) (<20 ng/mL) with the circulating bone turnover markers, when compared to their interaction with IGF-1. SUBJECTS AND

methodsSerum 25(OH)D, IGF-I, P1NP (N-terminal propeptide of type I procollagen), and CTX-1 (C-terminal telopeptide of type I collagen) were measured, and the bone turnover index (BTI) was calculated in 128 healthy children, aged 9-11 years.

resultsMean 25(OH)D concentration was 21.9 ± 4.9 ng/mL, but in 30.5% of participants it was <20 ng/mL (<50 nmol/L). We observed a trend for higher P1NP (

conclusionsLow levels of 25(OH)D do not unfavorably alter bone turnover. It seems that serum 25(OH)D level may not be an adequate predictor of bone turnover in children.

Indexed as

Bone RemodelingChildFemaleHumansInsulin-Like Growth Factor ILinear ModelsMalePubertyVitamin D25-hydroxyvitamin DInsulin-Like Growth Factor IVitamin D25-hydoxyvitamin Dbone mineral accrualbone turnover markersinsulin-like growth factor 1

Identifiers

PMID34684321
PMCPMC8537639

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.