Evidence map›Paper›PMID 34684302›Full record

ArticleNutrients2021

Triacylglycerides and Phospholipids from Egg Yolk Differently Influence the Immunostimulating Properties of Egg White Proteins.

Leticia Pérez-Rodríguez, Mónica Martínez-Blanco, Daniel Lozano-Ojalvo, Javier Fontecha, Elena Molina, Sara Benedé, Rosina López-Fandiño

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Leticia Pérez-RodríguezInstituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM), Nicolás Cabrera 9, 28049 Madrid, Spain.
Mónica Martínez-BlancoInstituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM), Nicolás Cabrera 9, 28049 Madrid, Spain.ORCID 0000-0003-1153-7957
Daniel Lozano-OjalvoIcahn School of Medicine at Mount Sinai, 1425 Madison Ave, 11-26, New York, NY 10029, USA.
Javier FontechaInstituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM), Nicolás Cabrera 9, 28049 Madrid, Spain.ORCID 0000-0001-5719-2304
Elena MolinaInstituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM), Nicolás Cabrera 9, 28049 Madrid, Spain.ORCID 0000-0001-7918-7768
Sara BenedéInstituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM), Nicolás Cabrera 9, 28049 Madrid, Spain.ORCID 0000-0002-9288-9438
Rosina López-FandiñoInstituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM), Nicolás Cabrera 9, 28049 Madrid, Spain.
Instituto de Investigación en Ciencias de la Alimentación · ESIcahn School of Medicine at Mount Sinai · US

Funding

Ministerio de Ciencia e Innovación AGL2017-88964-RMinisterio de Ciencia e Innovación Juan de la Cierva Incorporación contract
6 · The paper itself

Abstract

As part of a whole egg, egg white proteins are embedded in a lipid matrix that could modify their presentation to the immune system and their allergenic properties. The present study examines the impact of the main egg lipid components, triacylglycerides and phospholipids, in the early events of sensitization to egg. To this end, BALB/c mice were exposed intragastrically to egg lipids and egg lipid fractions, alone and in mixtures with egg white proteins, and Th2-promoting and proinflammatory effects were investigated. Our results highlight that the egg lipid fraction is responsible for Th2 adjuvant effects and point at a different influence of triacylglycerides and phospholipids on the bioavailability and immunomodulating properties of egg white proteins. While triacylglycerides promote type 2 responses at the small intestine level, phospholipids reduce the solubility of EW proteins and induce Th2 skewing in lymphoid intestinal tissues, which may have a direct impact on the development of egg allergy.

Indexed as

ImmunizationAnimalsChickensDuodenumEgg ProteinsEgg YolkFemaleGene Expression RegulationIntestine, SmallLymphocytesMiceMice, Inbred BALB CPhospholipidsSolubilityT-LymphocytesTriglyceridesEgg ProteinsPhospholipidsTriglyceridesdendritic cellsegg yolkfood allergygroup 2 innate lymphoid cellsphospholipidsTh2 responsestriacylglycerides

Identifiers

PMID34684302
PMCPMC8539141
OpenAlexW3204132964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.