Evidence map›Paper›PMID 34684293›Full record

ArticlePathogens (Basel, Switzerland)2021

Efficacy of a Modified Live Virus Vaccine against Porcine Reproductive and Respiratory Syndrome Virus 1 (PRRSV-1) Administered to 1-Day-Old Piglets in Front of Heterologous PRRSV-1 Challenge.

Heinrich Kreutzmann, Sophie Dürlinger, Christian Knecht, Michaela Koch, Marta Cabana, Gerard Torrent, Mònica Balasch, Lucas P Taylor, Gyula Balka, Wilhelm Gerner and 1 more

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
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  5. [Increased piglet losses upon exudative epidermitis - a case report].Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere · 2023
    Article
  6. Review
  7. Article
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  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Heinrich KreutzmannUniversity Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.
Sophie DürlingerUniversity Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.
Christian KnechtUniversity Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.
Michaela KochUniversity Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.
Marta CabanaZoetis Manufacturing and Research Spain S.L., Ctra. Camprodon s/n Finca La Riba, 17813 Girona, Spain.
Gerard TorrentZoetis Manufacturing and Research Spain S.L., Ctra. Camprodon s/n Finca La Riba, 17813 Girona, Spain.
Mònica BalaschZoetis Manufacturing and Research Spain S.L., Ctra. Camprodon s/n Finca La Riba, 17813 Girona, Spain.
Lucas P TaylorGlobal Development & Operations, Zoetis, Kalamazoo, MI 49007, USA.
Gyula BalkaDepartment of Pathology, University of Veterinary Medicine, 1078 Budapest, Hungary.ORCID 0000-0003-2742-173X
Wilhelm GernerInstitute of Immunology, Department of Pathobiology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.ORCID 0000-0002-2431-5889
Andrea LadinigUniversity Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.

Funding

Zoetis Spain No grant number
6 · The paper itself

Abstract

PRRSV is one of the most important viruses in the global swine industry and is often controlled by the use of modified live virus (MLV) vaccines. This study assessed the impact of a PRRSV-1 MLV vaccine applied to 1-day-old piglets challenged on day 28 of life with a PRRSV-1 field isolate (AUT15-33). Twenty-one piglets were vaccinated within 24 h of birth (T02), whereas 20 piglets were left unvaccinated (T01). Necropsy was performed two weeks post-challenge. Comparing the two groups, T02 piglets showed significantly higher (

Indexed as

1-day-old pigsAUT15-33cellular immune responseIFN-γMLVPRRSVsheddingvaccinationviremia

Identifiers

PMID34684293
PMCPMC8537468

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.