Evidence map›Paper›PMID 34684258›Full record

ReviewPathogens (Basel, Switzerland)2021

Bacterial Antibiotic Resistance: The Most Critical Pathogens.

Giuseppe Mancuso, Angelina Midiri, Elisabetta Gerace, Carmelo Biondo

Abstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 585 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
585citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

585 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Article
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  14. Genetic architecture and functional dynamics of integrons in Staphylococcus aureus resistance.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Review
  15. Antibiotics (Basel, Switzerland) · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

525 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Giuseppe MancusoDepartment of Human Pathology, University of Messina, 98125 Messina, Italy.
Angelina MidiriDepartment of Human Pathology, University of Messina, 98125 Messina, Italy.
Elisabetta GeraceIRCCS Centro Neurolesi "Bonino-Pulejo", 98100 Messina, Italy.
Carmelo BiondoDepartment of Human Pathology, University of Messina, 98125 Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotics have made it possible to treat bacterial infections such as meningitis and bacteraemia that, prior to their introduction, were untreatable and consequently fatal. Unfortunately, in recent decades overuse and misuse of antibiotics as well as social and economic factors have accelerated the spread of antibiotic-resistant bacteria, making drug treatment ineffective. Currently, at least 700,000 people worldwide die each year due to antimicrobial resistance (AMR). Without new and better treatments, the World Health Organization (WHO) predicts that this number could rise to 10 million by 2050, highlighting a health concern not of secondary importance. In February 2017, in light of increasing antibiotic resistance, the WHO published a list of pathogens that includes the pathogens designated by the acronym ESKAPE (

Indexed as

carbapenem-resistantESBLESKAPEmultidrug-resistant

Identifiers

PMID34684258
PMCPMC8541462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.