Evidence map›Paper›PMID 34684255›Full record

ArticlePathogens (Basel, Switzerland)2021

Host EPAC1 Modulates Rickettsial Adhesion to Vascular Endothelial Cells via Regulation of ANXA2 Y23 Phosphorylation.

Zhengchen Su, Thomas R Shelite, Yuan Qiu, Qing Chang, Maki Wakamiya, Jiani Bei, Xi He, Changcheng Zhou, Yakun Liu, Emmanuel Nyong and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. NETosis mediates tick blood pool formation.The Journal of veterinary medical science · 2026
    Article
  3. Article
  4. Annexin A2: A Double-Edged Sword in Pathogen Infection.Pathogens (Basel, Switzerland) · 2024
    Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Zhengchen SuDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Thomas R SheliteDivision of Infectious Disease, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.
Yuan QiuDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Qing ChangDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Maki WakamiyaDepartment of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Jiani BeiDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Xi HeDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Changcheng ZhouDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Yakun LiuDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Emmanuel NyongDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Yuejin LiangDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Angelo GaitasThe Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, 1468 Madison Ave, New York, NY 10029, USA.ORCID 0000-0003-4428-3949
Tais B SaitoThe Vector-Pathogen-Host Interaction Unit, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Bin GongDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
The University of Texas Medical Branch at Galveston · USIcahn School of Medicine at Mount Sinai · USNational Institutes of Health · US

Funding

Epac1 Plays a Critical Role in Bacterial Adhesion during RickettsiosesR01AI121012 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GONG, BIN · 2016 to 2020
$1.9M
The role of IL-1 family of cytokines in tick-transmitted ehrlichiosisR21AI144328 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GONG, BIN · 2019 to 2020
$435k
National Institute of Allergy and Infectious Diseases R01AI121012 (BG), R21AI137785 (BG), R21AI154211(BG), R03AI142406 (BG), R21AI144328 (TS and BG),NIAID NIH HHS R01 AI121012NIAID NIH HHS R21 AI144328
6 · The paper itself

Abstract

introductionIntracellular cAMP receptor exchange proteins directly activated by cAMP 1 (

methodsIn the present study, an established system that is anatomically based and quantifies bacterial adhesion to ECs in vivo was combined with novel fluidic force microscopy (FluidFM) to dissect the functional role of the

resultsThe deletion of the

conclusions

Indexed as

annexin A2bacterial adhesionendothelial cellEPAC1fluidic force microscopyrickettsiasingle living cell

Identifiers

PMID34684255
PMCPMC8537355
OpenAlexW3206615955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.