Evidence map›Paper›PMID 34684209›Full record

ArticlePathogens (Basel, Switzerland)2021

Evaluation of Gene Polymorphism and Gingival Crevicular Fluid Levels of Matrix Metalloproteinase-3 in a Group of Turkish Periodontitis Patients.

Gökhan Kasnak, Mustafa Yılmaz, Revan Birke Koca Ünsal, Nuray Gürel Polat, Erhan Fıratlı

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Gökhan KasnakDepartment of Periodontology, Faculty of Dentistry, Istanbul University-Cerrahpaşa, Istanbul 34098, Turkey.
Mustafa YılmazDepartment of Periodontology, Faculty of Dentistry, Biruni University, Istanbul 34010, Turkey.ORCID 0000-0002-2005-1417
Revan Birke Koca ÜnsalDepartment of Periodontology, Faculty of Dentistry, University of Kyrenia, Kyrenia 99320, Cyprus.ORCID 0000-0003-1540-983X
Nuray Gürel PolatVirology and Fundamental Immunology Unit, Faculty of Medicine, Istanbul University, Istanbul 34116, Turkey.
Erhan FıratlıDepartment of Periodontology, Faculty of Dentistry, Istanbul University, Istanbul 34116, Turkey.ORCID 0000-0002-4154-6929
Istanbul University · TRBiruni University · TRIstanbul University-Cerrahpaşa · TRUniversity of Kyrenia · CY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPeriodontitis is characterized by the destruction of tooth-supporting tissues. Matrix metalloproteinases (MMPs) play a significant part in the degradation of collagen structure. The gingival crevicular fluid (GCF) levels of MMPs increase with the progression of periodontal inflammation. Polymorphisms can be responsible for high expression of MMPs and can exacerbate the breakdown of collagen structure. This study aims to investigate the effect of MMP-3 -1171 5A/6A polymorphism and the GCF levels of MMP-3 in a group of Turkish periodontitis patients. MATERIALS AND

methodsNon-smoking, stage II grade A periodontitis (S II-Gr A) (

resultsThe MMP-3 -1179 5A/6A distribution showed no significant difference between the groups (

conclusionThe MMP-3 GCF levels showed an association with periodontal tissue destruction, although single nucleotide polymorphism was not associated with the S II-Gr C and S II-Gr A groups in the Turkish population.

Indexed as

matrix metalloproteinaseperiodontal diseasesingle nucleotide polymorphismstromelysin-1

Identifiers

PMID34684209
PMCPMC8539123
OpenAlexW3202052148

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.