Evidence map›Paper›PMID 34684062›Full record

ArticleMedicina (Kaunas, Lithuania)2021

IL-6 597A/G (rs1800797) and 174G/C (rs1800795) Gene Polymorphisms in the Development of Cervical Cancer in Lithuanian Women.

Agne Vitkauskaite, Joana Celiesiute, Vijoleta Juseviciute, Kristina Jariene, Erika Skrodeniene, Gabriele Samuolyte, Ruta Jolanta Nadisauskiene, Daiva Vaitkiene

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Association ofDiseases (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Article
  4. Polymorphisms of the interleukin-6 (Health science reports · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Agne VitkauskaiteDepartment of Obstetrics and Gynaecology, Medicine Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Joana CeliesiuteDepartment of Obstetrics and Gynaecology, Medicine Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Vijoleta JuseviciuteDepartment of Laboratory Medicine, Lithuanian University of Health Sciences Hospital, 50161 Kaunas, Lithuania.
Kristina JarieneDepartment of Obstetrics and Gynaecology, Medicine Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Erika SkrodenieneDepartment of Laboratory Medicine, Medicine Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Gabriele SamuolyteMedicine Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Ruta Jolanta NadisauskieneDepartment of Obstetrics and Gynaecology, Medicine Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Daiva VaitkieneDepartment of Obstetrics and Gynaecology, Medicine Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Lithuanian University of Health Sciences · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our study aimed to evaluate the distribution of genotypes and allele frequencies of IL-6 597A/G (rs1800797) and 174G/C (rs1800795) polymorphisms in HPV infected and uninfected healthy women and cervical cancer patients. A PCR based Multiplex HPV genotyping test kit was used for in vitro detection and differentiation of high risk HPV genotypes. Genotyping of two polymorphisms, IL-6 597A/G (rs1800797) and 174G/C (rs1800795), was performed using the KASP genotyping assay kit. Cervical cancer patients were more likely to be HPV positive than control patients. Allele C of IL-6 rs1800795 was associated with a higher risk of cervical cancer by 2.26-fold and genotype CC by 5.37-fold. Genotype CC of IL-6 rs1800795 was more frequent in the HPV positive group compared with the HPV negative group (

Indexed as

Papillomavirus InfectionsUterine Cervical NeoplasmsFemaleGenetic Predisposition to DiseaseGenotypeHuman papillomavirus 16HumansInterleukin-6Polymorphism, Single NucleotideIL6 protein, humanInterleukin-6cervical cancergene polymorphismsHPV

Identifiers

PMID34684062
PMCPMC8538235
OpenAlexW3202489379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.