Evidence map›Paper›PMID 34683940›Full record

ArticlePharmaceutics2021

Tumor-Targeted ZW800-1 Analog for Enhanced Tumor Imaging and Photothermal Therapy.

Min-Ho Park, Gayoung Jo, Eun-Jeong Kim, Hoon Hyun

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Lysosome-Targeted Bifunctional Therapeutics Induce Autodynamic Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Min-Ho ParkDepartment of Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun 58128, Korea.ORCID 0000-0003-1504-3815
Gayoung JoDepartment of Biomedical Sciences, Chonnam National University Medical School, Hwasun 58128, Korea.
Eun-Jeong KimDepartment of Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun 58128, Korea.
Hoon HyunDepartment of Biomedical Sciences, Chonnam National University Medical School, Hwasun 58128, Korea.ORCID 0000-0002-9106-6755
Chonnam National University Hwasun Hospital · KRChonnam National University · KR

Funding

National Research Foundation of Korea NRF-2021R1A2C1013465
6 · The paper itself

Abstract

ZW800-1, a representative zwitterionic near-infrared (NIR) fluorophore, can minimize background tissue uptake owing to its balanced surface charges, and therefore, is widely used for improved NIR fluorescence imaging. As ZW800-1 has no tumor targetability, tumor imaging is highly dependent on the ability of the molecules conjugated to the ZW800-1. To enable tumor targeting using ZW800-1 without additional conjugation, we developed a tumor-targetable and renal-clearable ZW800-1 analog (ZW800-AM) based on the structural modification of ZW800-1. Specifically, an amine group on the center linker of the ZW800-1 indocyanine backbone was modified by replacing phenoxypropionic acid with tyramine linkage on the

Indexed as

near-infrared fluorescence imagingphotothermal therapytumor targetingZW800-1zwitterionic fluorophores

Identifiers

PMID34683940
PMCPMC8537849
OpenAlexW3207082987

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.