Evidence map›Paper›PMID 34683932›Full record

ArticlePharmaceutics2021

Antimicrobial Activities of Chitosan Derivatives.

Cristina Ardean, Corneliu Mircea Davidescu, Nicoleta Sorina Nemeş, Adina Negrea, Mihaela Ciopec, Narcis Duteanu, Petru Negrea, Daniel Duda-Seiman, Delia Muntean

Abstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cristina ArdeanFaculty of Industrial Chemistry and Environmental Engineering, Politehnica University of Timişoara, 2 Piata Victoriei, 300006 Timisoara, Romania.
Corneliu Mircea DavidescuRenewable Energy Research Institute-ICER, University Politehnica of Timisoara, 138 Gavril Musicescu Street, 300501 Timisoara, Romania.ORCID 0000-0003-2423-2490
Nicoleta Sorina NemeşRenewable Energy Research Institute-ICER, University Politehnica of Timisoara, 138 Gavril Musicescu Street, 300501 Timisoara, Romania.ORCID 0000-0003-2532-2893
Adina NegreaFaculty of Industrial Chemistry and Environmental Engineering, Politehnica University of Timişoara, 2 Piata Victoriei, 300006 Timisoara, Romania.ORCID 0000-0001-7572-3703
Mihaela CiopecFaculty of Industrial Chemistry and Environmental Engineering, Politehnica University of Timişoara, 2 Piata Victoriei, 300006 Timisoara, Romania.
Narcis DuteanuFaculty of Industrial Chemistry and Environmental Engineering, Politehnica University of Timişoara, 2 Piata Victoriei, 300006 Timisoara, Romania.ORCID 0000-0002-5015-9306
Petru NegreaFaculty of Industrial Chemistry and Environmental Engineering, Politehnica University of Timişoara, 2 Piata Victoriei, 300006 Timisoara, Romania.
Daniel Duda-SeimanDepartment of Cardiology, Victor Babes University of Medicine and Pharmacy Timişoara, 2 Piata Eftimie Murgu, 300041 Timisoara, Romania.
Delia MunteanMultidisciplinary Research Center on Antimicrobial Resistance, Department of Microbiology, Victor Babes University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.ORCID 0000-0001-9100-4530

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considering the challenge created by the development of bacterial and fungal strains resistant to multiple therapeutic variants, new molecules and materials with specific properties against these microorganisms can be synthesized, like those synthesized from biopolymers such as chitosan with improved antimicrobial activities. Antimicrobial activities of seven obtained materials were tested on four reference strains belonging to American Type Culture Collection. The best antimicrobial activity was obtained by functionalization by impregnation of chitosan with quaternary ammonium salts, followed by that obtained by functionalization of chitosan with phosphonium. The lowest antibacterial and antifungal effects were expressed by Ch-THIO and Ch-MBT, but new materials obtained with these extractants may be precursors with a significant role in the direct control of active molecules, such as cell growth factors or cell signaling molecules.

Indexed as

antibacterial activitiesantifungal activitieschitosanfunctionalization by impregnation

Identifiers

PMID34683932
PMCPMC8541518

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.