Evidence map›Paper›PMID 34683910›Full record

ReviewPharmaceutics2021

Nanotechnology Addressing Cutaneous Melanoma: The Italian Landscape.

Luigi Battaglia, Anna Scomparin, Chiara Dianzani, Paola Milla, Elisabetta Muntoni, Silvia Arpicco, Roberta Cavalli

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Nanotechnology as a Promising Method in the Treatment of Skin Cancer.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luigi Battaglia. Department of Drug Science and Technology, University of Torino, 10125 Turin, Italy.ORCID 0000-0002-5081-3638
Anna Scomparin. Department of Drug Science and Technology, University of Torino, 10125 Turin, Italy.ORCID 0000-0003-4751-620X
Chiara Dianzani. Department of Drug Science and Technology, University of Torino, 10125 Turin, Italy.ORCID 0000-0002-2246-3183
Paola Milla. Department of Drug Science and Technology, University of Torino, 10125 Turin, Italy.ORCID 0000-0002-4245-4161
Elisabetta Muntoni. Department of Drug Science and Technology, University of Torino, 10125 Turin, Italy.ORCID 0000-0002-9739-6667
Silvia Arpicco. Department of Drug Science and Technology, University of Torino, 10125 Turin, Italy.
Roberta Cavalli. Department of Drug Science and Technology, University of Torino, 10125 Turin, Italy.

Funding

Fondazione CRT project 2019 2252
6 · The paper itself

Abstract

Cutaneous melanoma is one of the most aggressive solid tumors, with a low survival for the metastatic stage. Currently, clinical melanoma treatments include surgery, chemotherapy, targeted therapy, immunotherapy and radiotherapy. Of note, innovative therapeutic regimens concern the administration of multitarget drugs in tandem, in order to improve therapeutic efficacy. However, also, if this drug combination is clinically relevant, the patient's response is not yet optimal. In this scenario, nanotechnology-based delivery systems can play a crucial role in the clinical treatment of advanced melanoma. In fact, their nano-features enable targeted drug delivery at a cellular level by overcoming biological barriers. Various nanomedicines have been proposed for the treatment of cutaneous melanoma, and a relevant number of them are undergoing clinical trials. In Italy, researchers are focusing on the pharmaceutical development of nanoformulations for malignant melanoma therapy. The present review reports an overview of the main melanoma-addressed nanomedicines currently under study in Italy, alongside the state of the art of melanoma therapy. Moreover, the latest Italian advances concerning the pre-clinical evaluation of nanomedicines for melanoma are described.

Indexed as

Italymelanomananoparticlesnanotechnology

Identifiers

PMID34683910
PMCPMC8540596

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.