Evidence map›Paper›PMID 34683907›Full record

ArticlePharmaceutics2021

Angiotensin-(1-7) Peptide Hormone Reduces Inflammation and Pathogen Burden during

Katie L Collins, Usir S Younis, Sasipa Tanyaratsrisakul, Robin Polt, Meredith Hay, Heidi M Mansour, Julie G Ledford

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Angiotensin-(1-7) decreases inflammation and lung damage caused by betacoronavirus infection in mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Article
  3. Review
  4. Article
  5. Advances in Biomarkers for Diagnosis and Treatment of ARDS.Diagnostics (Basel, Switzerland) · 2023
    Review
  6. Article
  7. Fucoxanthin, a Marine Carotenoid, SuppressesEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Katie L CollinsDepartment of Immunobiology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA.
Usir S YounisAsthma and Airway Disease Research Center, Tucson, AZ 85724, USA.
Sasipa TanyaratsrisakulAsthma and Airway Disease Research Center, Tucson, AZ 85724, USA.
Robin PoltDepartments of Chemistry and Biochemistry, College of Science, The University of Arizona, Tucson, AZ 85721, USA.ORCID 0000-0003-0756-3183
Meredith HayDepartment of Physiology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA.
Heidi M MansourBIO5 Institute, The University of Arizona, Tucson, AZ 85719, USA.ORCID 0000-0003-3993-9210
Julie G LedfordAsthma and Airway Disease Research Center, Tucson, AZ 85724, USA.ORCID 0000-0001-7977-4575
University of Arizona · USDermatology Research Center · US

Funding

IND Enabling Studies for a Novel Mas Receptor Agonist for Treatment of Cognitive Impairment in Patients at Risk for Alzheimer's Disease Related DementiaU01AG066623 · NIA · UNIVERSITY OF ARIZONA · PI HAY, MEREDITH, KONHILAS, JOHN P · 2020 to 2023
$8.0M
Defining mechanisms of CC16 on epithelial-driven host responses to pathogensR01HL142769 · NHLBI · UNIVERSITY OF ARIZONA · PI Julie Gunnells Ledford · 2019 to 2026
$4.2M
Perinatal NO signaling in congenital heart diseaseR01HL137282 · NHLBI · UNIVERSITY OF ARIZONA · PI BLACK, STEPHEN M, FINEMAN, JEFFREY R · 2017 to 2020
$2.7M
Surfactant Protein A as a Novel Therapeutic for AsthmaR21AI135935 · NIAID · UNIVERSITY OF ARIZONA · PI LEDFORD, JULIE GUNNELLS, MANSOUR, HEIDI M. · 2018 to 2019
$422k
National Institute of Allergy and Infectious Diseases AI135935NHLBI NIH HHS HL142769NHLBI NIH HHS R01 HL137282NHLBI NIH HHS R01 HL142769NIA NIH HHS U01 AG066623
6 · The paper itself

Abstract

The peptide hormone, angiotensin (Ang-(1-7)), produces anti-inflammatory and protective effects by inhibiting production and expression of many cytokines and adhesion molecules that are associated with a cytokine storm. While Ang-(1-7) has been shown to reduce inflammation and airway hyperreactivity in models of asthma, little is known about the effects of Ang-(1-7) during live respiratory infections. Our studies were developed to test if Ang-(1-7) is protective in the lung against overzealous immune responses during an infection with

Indexed as

angiotensin-(1–7)asthmainflammationmacrophagesMycoplasma pneumoniae

Identifiers

PMID34683907
PMCPMC8539524
OpenAlexW3203409362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.