Evidence map›Paper›PMID 34683848›Full record

ArticlePharmaceutics2021

Multiomics Identification of Potential Targets for Alzheimer Disease and Antrocin as a Therapeutic Candidate.

Alexander T H Wu, Bashir Lawal, Li Wei, Ya-Ting Wen, David T W Tzeng, Wen-Cheng Lo

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

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  9. Arabian journal of chemistry · 2023
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  17. Identification ofBiomedicines · 2021
    Article
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  19. Journal of inflammation research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Alexander T H WuThe Ph.D. Program of Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0002-0178-6530
Bashir LawalPhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan.ORCID 0000-0003-0676-5875
Li WeiGraduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei 11031, Taiwan.
Ya-Ting WenDepartment of Neurosurgery, Taipei Medical University-Wan Fang Hospital, Taipei 11031, Taiwan.
David T W TzengSchool of Life Sciences, The Chinese University of Hong Kong, Hong Kong 999077, China.
Wen-Cheng LoSchool of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Taipei Medical University Hospital · TWWan Fang Hospital · TWChinese University of Hong Kong · HKTaipei Medical University · TW

Funding

Ministry of Science and Technology, Taiwan DP2-110-21121-03-C-09
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most frequent cause of neurodegenerative dementia and affects nearly 50 million people worldwide. Early stage diagnosis of AD is challenging, and there is presently no effective treatment for AD. The specific genetic alterations and pathological mechanisms of the development and progression of dementia remain poorly understood. Therefore, identifying essential genes and molecular pathways that are associated with this disease's pathogenesis will help uncover potential treatments. In an attempt to achieve a more comprehensive understanding of the molecular pathogenesis of AD, we integrated the differentially expressed genes (DEGs) from six microarray datasets of AD patients and controls. We identified ATPase H+ transporting V1 subunit A (

Indexed as

Alzheimer’s diseaseantrocinbiomarker identificationin silico pharmacological analysestherapeutic innovation

Identifiers

PMID34683848
PMCPMC8539161
OpenAlexW3203305574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.