Evidence map›Paper›PMID 34683834›Full record

ArticlePharmaceutics2021

Anticancer Activity of Half-Sandwich Ru, Rh and Ir Complexes with Chrysin Derived Ligands: Strong Effect of the Side Chain in the Ligand and Influence of the Metal.

Ana R Rubio, Rocío González, Natalia Busto, Mónica Vaquero, Ana L Iglesias, Félix A Jalón, Gustavo Espino, Ana M Rodríguez, Begoña García, Blanca R Manzano

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 23 citations in OpenAlex.

  1. Tailoring the biological activity of oxorhenium(V) complexes through Chrysin ligand functionalization.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ana R RubioDepartamento de Química, Facultad de Ciencias, Universidad de Burgos, Plaza Misael Bañuelos s/n, 09001 Burgos, Spain.
Rocío GonzálezFacultad de Ciencias y Tecnologías Químicas-IRICA, Universidad de Castilla-La Mancha, Avda. C. J. Cela 10, 13071 Ciudad Real, Spain.
Natalia BustoDepartamento de Química, Facultad de Ciencias, Universidad de Burgos, Plaza Misael Bañuelos s/n, 09001 Burgos, Spain.ORCID 0000-0001-9637-1209
Mónica VaqueroDepartamento de Química, Facultad de Ciencias, Universidad de Burgos, Plaza Misael Bañuelos s/n, 09001 Burgos, Spain.ORCID 0000-0002-4550-4072
Ana L IglesiasFacultad de Ciencias y Tecnologías Químicas-IRICA, Universidad de Castilla-La Mancha, Avda. C. J. Cela 10, 13071 Ciudad Real, Spain.ORCID 0000-0002-7953-6910
Félix A JalónFacultad de Ciencias y Tecnologías Químicas-IRICA, Universidad de Castilla-La Mancha, Avda. C. J. Cela 10, 13071 Ciudad Real, Spain.
Gustavo EspinoDepartamento de Química, Facultad de Ciencias, Universidad de Burgos, Plaza Misael Bañuelos s/n, 09001 Burgos, Spain.
Ana M RodríguezDepartamento de Química Inorgánica, Orgánica y Bioquímica, Escuela Técnica Superior de Ingenieros Industriales, Universidad de Castilla-La Mancha, Avda. C. J. Cela 2, 13071 Ciudad Real, Spain.
Begoña GarcíaDepartamento de Química, Facultad de Ciencias, Universidad de Burgos, Plaza Misael Bañuelos s/n, 09001 Burgos, Spain.
Blanca R ManzanoFacultad de Ciencias y Tecnologías Químicas-IRICA, Universidad de Castilla-La Mancha, Avda. C. J. Cela 10, 13071 Ciudad Real, Spain.
Universidad de Burgos · ESUniversity of Castilla-La Mancha · ESUniversidad Autónoma de Baja California · MX

Funding

COST-Action CA18202Junta de Castilla y León BU087G19 and BU305P18Junta de Comunidades de Castilla-La Mancha SBPLY/19/180501/000260"la Caixa" Foundation LCF/PR/PR12/11070003Ministerio de Ciencia, Innovación y Universidades RTI2018-100709-B-C21Ministerio de Ciencia, Innovación y Universidades RTI2018-102040-B-100Universidad de Castilla-La Mancha 2019-GRIN-27183Universidad de Castilla-La Mancha 2019-GRIN-27209
6 · The paper itself

Abstract

An important challenge in the field of anticancer chemotherapy is the search for new species to overcome the resistance of standard drugs. An interesting approach is to link bioactive ligands to metal fragments. In this work, we have synthesized a set of

Indexed as

cancerchrysin ligandshalf-sandwichiridiummetallodrugspiperidinerhodiumruthenium

Identifiers

PMID34683834
PMCPMC8537477
OpenAlexW3199694819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.