Evidence map›Paper›PMID 34683825›Full record

ArticlePharmaceutics2021

Melatonin Improves Levels of Zn and Cu in the Muscle of Diabetic Obese Rats.

Miguel Navarro-Alarcón, Fernando Gil-Hernández, Cristina Sánchez-González, Juan Llopis, Marina Villalón-Mir, Pablo Olmedo, Pablo Alarcón-Guijo, Diego Salagre, Lorena Gaona, Mario Paredes and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Miguel Navarro-AlarcónDepartment of Nutrition and Bromatology, School of Pharmacy, University of Granada, 18016 Granada, Spain.ORCID 0000-0002-3189-3310
Fernando Gil-HernándezDepartment of Toxicology, School of Medicine, University of Granada, 18071 Granada, Spain.ORCID 0000-0001-9816-8618
Cristina Sánchez-GonzálezDepartment of Physiology, Institute of Nutrition and Food Science, Biomedical Research Centre, University of Granada, 18071 Granada, Spain.ORCID 0000-0002-1044-4858
Juan LlopisDepartment of Physiology, Institute of Nutrition and Food Science, Biomedical Research Centre, University of Granada, 18071 Granada, Spain.ORCID 0000-0001-6803-2584
Marina Villalón-MirDepartment of Nutrition and Bromatology, School of Pharmacy, University of Granada, 18016 Granada, Spain.
Pablo OlmedoDepartment of Toxicology, School of Medicine, University of Granada, 18071 Granada, Spain.
Pablo Alarcón-GuijoDepartment of Pharmacology, Biohealth Institute and Neurosciences Institute, School of Medicine, University of Granada, 18016 Granada, Spain.ORCID 0000-0001-6243-7708
Diego SalagreDepartment of Pharmacology, Biohealth Institute and Neurosciences Institute, School of Medicine, University of Granada, 18016 Granada, Spain.ORCID 0000-0003-2888-6272
Lorena GaonaDepartment of Pharmacology, Biohealth Institute and Neurosciences Institute, School of Medicine, University of Granada, 18016 Granada, Spain.
Mario ParedesDepartment of Pharmacology, Biohealth Institute and Neurosciences Institute, School of Medicine, University of Granada, 18016 Granada, Spain.
Ahmad AgilDepartment of Pharmacology, Biohealth Institute and Neurosciences Institute, School of Medicine, University of Granada, 18016 Granada, Spain.ORCID 0000-0003-0164-9648
Universidad de Granada · ES

Funding

European Regional Development Fund SAF2016-79794-R
6 · The paper itself

Abstract

Melatonin improves metabolic alterations associated with obesity and its diabetes (diabesity). We intend to determine whether this improvement is exerted by changing Zn and/or Cu tissue levels in liver, muscle, pancreas, and brain, and in internal (perirenal, perigonadal, and omentum) and subcutaneous lumbar white adipose tissues (IWAT and SWAT, respectively). Male Zücker diabetic fatty (ZDF) rats and lean littermates (ZL) were orally supplemented either with melatonin (10 mg/kg body weight/day) or vehicle for 6 weeks. Zn and Cu concentrations were not significantly influenced by diabesity in the analyzed tissues (

Indexed as

copperdiabetic obese ratmelatoninmuscle and other organ and white adipose tissueszinc

Identifiers

PMID34683825
PMCPMC8539996
OpenAlexW3199376976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.