Evidence map›Paper›PMID 34683705›Full record

ArticleMaterials (Basel, Switzerland)2021

Nanocomplex of Berberine with C

Iryna Horak, Svitlana Prylutska, Iryna Krysiuk, Serhii Luhovskyi, Oleksii Hrabovsky, Nina Tverdokhleb, Daria Franskevych, Dmytro Rumiantsev, Anton Senenko, Maxim Evstigneev and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 4 countries.

Iryna HorakPalladin Institute of Biochemistry, NAS of Ukraine, 9 Leontovicha Str., 01030 Kyiv, Ukraine.
Svitlana PrylutskaFaculty of Plant Ptotection, Biotechnology and Ecology, National University of Life and Environmental Science of Ukraine, 15 Heroiv Oborony Str., 03041 Kyiv, Ukraine.
Iryna KrysiukPalladin Institute of Biochemistry, NAS of Ukraine, 9 Leontovicha Str., 01030 Kyiv, Ukraine.
Serhii LuhovskyiChebotarov Institute of Gerontology, NAS of Ukraine, 67 Vyshgorodska Str., 04114 Kyiv, Ukraine.
Oleksii HrabovskyPalladin Institute of Biochemistry, NAS of Ukraine, 9 Leontovicha Str., 01030 Kyiv, Ukraine.ORCID 0000-0001-6690-2398
Nina TverdokhlebLeibniz Institute of Polymer Research Dresden, 6 Hohe Str., 01069 Dresden, Germany.ORCID 0000-0002-2335-0260
Daria FranskevychDepartment of Biophysics and Medical Informatics, Taras Shevchenko National University of Kyiv, 64 Volodymyrska Str., 01601 Kyiv, Ukraine.
Dmytro RumiantsevInstitute of Physics, NAS of Ukraine, 46 Nauky Ave., 03028 Kyiv, Ukraine.
Anton SenenkoInstitute of Physics, NAS of Ukraine, 46 Nauky Ave., 03028 Kyiv, Ukraine.ORCID 0000-0003-4347-695X
Maxim EvstigneevDepartment of Biology and Chemistry, Belgorod State University, 85 Pobedy Str., 308015 Belgorod, Russia.
Liudmyla DrobotPalladin Institute of Biochemistry, NAS of Ukraine, 9 Leontovicha Str., 01030 Kyiv, Ukraine.
Olga MatyshevskaPalladin Institute of Biochemistry, NAS of Ukraine, 9 Leontovicha Str., 01030 Kyiv, Ukraine.
Uwe RitterInstitute of Chemistry and Biotechnology, Technical University of Ilmenau, 25 Weimarer Str., 98693 Ilmenau, Germany.ORCID 0000-0002-9315-4863
Jacek PiosikIntercollegiate Faculty of Biotechnology, UG-MUG (University of Gdansk and Medical University of Gdansk), Abrahama 58, 80-307 Gdańsk, Poland.ORCID 0000-0002-5671-1915
Yuriy PrylutskyyDepartment of Biophysics and Medical Informatics, Taras Shevchenko National University of Kyiv, 64 Volodymyrska Str., 01601 Kyiv, Ukraine.
Palladin Institute of Biochemistry · UAInstitute of Physics · UATaras Shevchenko National University of Kyiv · UABelgorod National Research University · RUD.F. Chebotarev Institute of Gerontology · UAGdańsk Medical University · PLLeibniz Institute of Polymer Research · DENational University of Life and Environmental Sciences of Ukraine · UATechnische Universität Ilmenau · DE

Funding

National Research Foundation of Ukraine 2020.02/0060
6 · The paper itself

Abstract

Effective targeting of metastasis is considered the main problem in cancer therapy. The development of herbal alkaloid Berberine (Ber)-based anticancer drugs is limited due to Ber' low effective concentration, poor membrane permeability, and short plasma half-life. To overcome these limitations, we used Ber noncovalently bound to C

Indexed as

BerberineC60 fullereneLewis lung carcinomalung cancer cellsmetastasis in vivonanocomplex

Identifiers

PMID34683705
PMCPMC8540026
OpenAlexW3207722893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.