ArticleMicroorganisms2021
Detection of Clinical and Subclinical Lumpy Skin Disease Using Ear Notch Testing and Skin Biopsies.
Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Selective culling and the potential persistence of lumpy skin disease in cattle herds: insights from a mechanistic transmission model.Veterinary research · 2026Article
- Robust multi-class lumpy skin disease diagnosis for practical livestock applications.Scientific reports · 2026Article
- Diagnostic approach, vaccination and treatment priorities for Lumpy Skin Disease in cattle: lessons from Balkan epidemics to Western Europe re-emergence (2025).Veterinary research communications · 2026Review
- Demonstration of the pathogenicity of LSDV pendik strain in cattle.Archives of virology · 2026Article
- Review
- Clinical and molecular description of natural infections with an Asian strain of lumpy skin disease virus in Bos indicus.Scientific reports · 2025Article
- Lumpy Skin Disease: Insights into Molecular Pathogenesis and Control Strategies.Veterinary sciences · 2024Review
- Characterization and molecular identification of the lumpy skin disease virus in cattle in the Mekong Delta of Vietnam.Open veterinary journal · 2024Article
- Susceptibility of Mediterranean Buffalo (Viruses · 2024Article
- Subclinical infection caused by a recombinant vaccine-like strain poses high risks of lumpy skin disease virus transmission.Frontiers in veterinary science · 2024Article
- Evidence of Lumpy Skin Disease Virus Transmission from Subclinically Infected Cattle byViruses · 2023Article
- Lumpy skin disease: history, current understanding and research gaps in the context of recent geographic expansion.Frontiers in microbiology · 2023Review
- Lumpy skin disease: A newly emerging disease in Southeast Asia.Veterinary world · 2022Review
- Molecular identification and characterization of Lumpy skin disease virus emergence from cattle in the northeastern part of Thailand.Journal of veterinary science · 2022Article
- A Recombinant Vaccine-like Strain of Lumpy Skin Disease Virus Causes Low-Level Infection of Cattle through Virus-Inoculated Feed.Pathogens (Basel, Switzerland) · 2022Article
- The immune response to lumpy skin disease virus in cattle is influenced by inoculation route.Frontiers in immunology · 2022Article
- Experimentally controlled study indicates that the naturally occurring recombinant vaccine-like lumpy skin disease strain Udmurtiya/2019, detected during freezing winter in northern latitudes, is transmittedFrontiers in veterinary science · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Lumpy skin disease (LSD) diagnosis is primarily based on clinical surveillance complemented by PCR of lesion crusts or nodule biopsies. Since LSD can be subclinical, the sensitivity of clinical surveillance could be lower than expected. Furthermore, real-time PCR for the detection of LSD viral DNA in blood samples from subclinical animals is only intermittently positive. Therefore, this study aimed to investigate an acceptable, easily applicable and more sensitive testing method for the detection of clinical and subclinical LSD. An animal experiment was conducted to investigate ear notches and biopsies from unaffected skin taken from the neck and dorsal back as alternatives to blood samples. It was concluded that for early LSD confirmation, normal skin biopsies and ear notches are less fit for purpose, as LSDV DNA is only detectable in these samples several days after it is detectable in blood samples. On the other hand, blood samples are less advisable for the detection of subclinical animals, while ear notches and biopsies were positive for LSD viral DNA in all subclinically infected animals by 16 days post infection. In conclusion, ear notches could be used for surveillance to detect subclinical animals after removing the clinical animals from a herd, to regain trade by substantiating the freedom of disease or to support research on LSDV transmission from subclinical animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.