Evidence map›Paper›PMID 34683480›Full record

ArticleMicroorganisms2021

The Combined Use of Cytokine Serum Values with Laboratory Parameters Improves Mortality Prediction of COVID-19 Patients: The Interleukin-15-to-Albumin Ratio.

Salma A Rizo-Téllez, Lucia A Méndez-García, Ana C Rivera-Rugeles, Marcela Miranda-García, Aarón N Manjarrez-Reyna, Rebeca Viurcos-Sanabria, Helena Solleiro-Villavicencio, Enrique Becerril-Villanueva, José D Carrillo-Ruíz, Julian M Cota-Arce and 3 more

Abstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Dynamic Cytokine and Coagulation Profiling in Patients With Severe COVID‑19 Evaluated for Pulmonary Embolism: A Prospective Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Observational
  2. Article
  3. Article
  4. Article
  5. The Combined Use of Interleukin-6 with Serum Albumin for Mortality Prediction in Critically Ill Elderly Patients: The Interleukin-6-to-albumin Ratio.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Salma A Rizo-TéllezLaboratory of Immunometabolism, Research Division, General Hospital of Mexico "Dr. Eduardo Liceaga", Mexico City 06720, Mexico.ORCID 0000-0003-0587-5167
Lucia A Méndez-GarcíaLaboratory of Immunometabolism, Research Division, General Hospital of Mexico "Dr. Eduardo Liceaga", Mexico City 06720, Mexico.ORCID 0000-0001-7576-5209
Ana C Rivera-RugelesLaboratory of Oncoimmunology, Biomedical Research Unit, Universidad Nacional Autónoma de México, Tlalnepantla 54090, Mexico.
Marcela Miranda-GarcíaLaboratory of Immunometabolism, Research Division, General Hospital of Mexico "Dr. Eduardo Liceaga", Mexico City 06720, Mexico.ORCID 0000-0002-2905-2571
Aarón N Manjarrez-ReynaLaboratory of Immunometabolism, Research Division, General Hospital of Mexico "Dr. Eduardo Liceaga", Mexico City 06720, Mexico.ORCID 0000-0002-5194-228X
Rebeca Viurcos-SanabriaLaboratory of Immunometabolism, Research Division, General Hospital of Mexico "Dr. Eduardo Liceaga", Mexico City 06720, Mexico.
Helena Solleiro-VillavicencioPosgrado de Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, Mexico City 03100, Mexico.
Enrique Becerril-VillanuevaLaboratory of Psychoimmunology, National Institute of Psychiatry "Ramón de la Fuente", Mexico City 14370, Mexico.ORCID 0000-0001-7210-9775
José D Carrillo-RuízResearch Directorate, General Hospital of Mexico "Dr. Eduardo Liceaga", Mexico City 06726, Mexico.
Julian M Cota-ArceDepartment of Biomedical Innovation, Center for Scientific Research and Higher Education of Ensenada (CICESE), Ensenada 22860, Mexico.
Angélica Álvarez-LeeDepartment of Biomedical Innovation, Center for Scientific Research and Higher Education of Ensenada (CICESE), Ensenada 22860, Mexico.
Marco A De León-NavaDepartment of Biomedical Innovation, Center for Scientific Research and Higher Education of Ensenada (CICESE), Ensenada 22860, Mexico.ORCID 0000-0003-1873-6676
Galileo EscobedoLaboratory of Immunometabolism, Research Division, General Hospital of Mexico "Dr. Eduardo Liceaga", Mexico City 06720, Mexico.ORCID 0000-0002-9224-7400

Funding

Consejo Nacional de Ciencia y Tecnología CB-2016-01-286209Consejo Nacional de Ciencia y Tecnología SALUD-2017-02-290345
6 · The paper itself

Abstract

Laboratory parameters display limited accuracy in predicting mortality in coronavirus disease 2019 (COVID-19) patients, as with serum albumin. Emerging evidence suggests that cytokine serum values may enhance the predictive capacity of albumin, especially interleukin (IL)-15. We thus investigated whether the use of the IL-15-to-albumin ratio enables improving mortality prediction at hospital admission in a large group of COVID-19 patients. In this prospective cross-sectional study, we enrolled and followed up three hundred and seventy-eight patients with a COVID-19 diagnosis until hospital discharge or death. Two hundred and fifty-five patients survived, whereas one hundred and twenty-three died. Student's

Indexed as

albuminCOVID-19IL-15mortalityprognosisSARS-CoV-2

Identifiers

PMID34683480
PMCPMC8539806

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.