Evidence map›Paper›PMID 34683450›Full record

ReviewMicroorganisms2021

Microbiomics in Collusion with the Nervous System in Carcinogenesis: Diagnosis, Pathogenesis and Treatment.

Rodney Hull, Georgios Lolas, Stylianos Makrogkikas, Lasse D Jensen, Konstantinos N Syrigos, George Evangelou, Llewellyn Padayachy, Cyril Egbor, Ravi Mehrotra, Tshepiso Jan Makhafola and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 4 countries.

Rodney HullSAMRC Precision Oncology Research Unit (PORU), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0028, South Africa.
Georgios LolasSAMRC Precision Oncology Research Unit (PORU), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0028, South Africa.
Stylianos MakrogkikasFALCONBIO PTE, Ltd., 32 Carpenter Street, SGInnovate, Singapore 059911, Singapore.
Lasse D JensenDivision of Cardiovascular Medicine, Department of Health, Medicine and Caring Sciences, Faculty of Medicine, Linköping University, 581 83 Linköping, Sweden.ORCID 0000-0003-2338-357X
Konstantinos N SyrigosDepartment of Medicine, National & Kapodistrian University of Athens, 11527 Athens, Greece.
George EvangelouDepartment of Medicine, National & Kapodistrian University of Athens, 11527 Athens, Greece.
Llewellyn PadayachySAMRC Precision Oncology Research Unit (PORU), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0028, South Africa.ORCID 0000-0003-0292-5587
Cyril EgborSAMRC Precision Oncology Research Unit (PORU), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0028, South Africa.
Ravi MehrotraSAMRC Precision Oncology Research Unit (PORU), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0028, South Africa.ORCID 0000-0001-9453-1408
Tshepiso Jan MakhafolaSAMRC Precision Oncology Research Unit (PORU), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0028, South Africa.ORCID 0000-0002-8335-9611
Meryl OyomnoSAMRC Precision Oncology Research Unit (PORU), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0028, South Africa.ORCID 0000-0002-6102-3826
Zodwa DlaminiSAMRC Precision Oncology Research Unit (PORU), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0028, South Africa.ORCID 0000-0002-8012-3646
South African Medical Research Council · ZANational and Kapodistrian University of Athens · GRLinköping University · SE

Funding

South African Medical Research Council 00000
6 · The paper itself

Abstract

The influence of the naturally occurring population of microbes on various human diseases has been a topic of much recent interest. Not surprisingly, continuously growing attention is devoted to the existence of a gut brain axis, where the microbiota present in the gut can affect the nervous system through the release of metabolites, stimulation of the immune system, changing the permeability of the blood-brain barrier or activating the vagus nerves. Many of the methods that stimulate the nervous system can also lead to the development of cancer by manipulating pathways associated with the hallmarks of cancer. Moreover, neurogenesis or the creation of new nervous tissue, is associated with the development and progression of cancer in a similar manner as the blood and lymphatic systems. Finally, microbes can secrete neurotransmitters, which can stimulate cancer growth and development. In this review we discuss the latest evidence that support the importance of microbiota and peripheral nerves in cancer development and dissemination.

Indexed as

carcinogenesisgut–brain axisimmunitymetabolitesmicrobiotaneurogenesisneurotransmitters

Identifiers

PMID34683450
PMCPMC8538279
OpenAlexW3205197711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.