Evidence map›Paper›PMID 34683449›Full record

ArticleMicroorganisms2021

Evaluation of Tetracycline Resistance and Determination of the Tentative Microbiological Cutoff Values in Lactic Acid Bacterial Species.

Qingqing Ma, Zhangming Pei, Zhifeng Fang, Hongchao Wang, Jinlin Zhu, Yuan-Kun Lee, Hao Zhang, Jianxin Zhao, Wenwei Lu, Wei Chen

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  6. Review
  7. Comparative genomic analysis of theComputational and structural biotechnology journal · 2025
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  10. The Effects ofMicroorganisms · 2023
    Review
  11. Applied and environmental microbiology · 2023
    Article
  12. Article
  13. Antimicrobial Resistance of Lactic Acid Bacteria fromAntibiotics (Basel, Switzerland) · 2023
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Qingqing MaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0002-6775-7695
Zhangming PeiState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0001-5598-9280
Zhifeng FangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Hongchao WangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0001-7148-7555
Jinlin ZhuState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Yuan-Kun LeeDepartment of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.ORCID 0000-0002-3884-4706
Hao ZhangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0002-9192-4684
Jianxin ZhaoState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Wenwei LuState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Wei ChenState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Jiangnan University · CN

Funding

National Key Research and Development Program of China No.2019YFF0217601National Natural Science Foundation of China No. 31820103010
6 · The paper itself

Abstract

Lactic acid bacteria (LAB) are widely used as probiotics in the food industry owing to their beneficial effects on human health. However, numerous antibiotic resistance genes have been found in LAB strains, especially tetracycline resistance genes. Notably, the potential transferability of these genes poses safety risks. To comprehensively evaluate tetracycline resistance in LAB, we determined the tetracycline susceptibility patterns of 478 LAB strains belonging to four genera and eight species. By comparing phenotypes with genotypes based on genome-wide annotations, five tetracycline resistance genes, tet(M), tet(W/N/W), tet(L), tet(S), and tet(45), were detected in LAB. Multiple LAB strains without tetracycline resistance genes were found to be resistant to tetracycline at the currently recommended cutoff values. Thus, based on the minimum inhibitory concentrations of tetracycline for these LAB strains, the species-specific microbiological cutoff values for

Indexed as

lactic acid bacteriamicrobiological cutoff valueminimum inhibitory concentrationtetracycline resistancetetracycline resistance gene

Identifiers

PMID34683449
PMCPMC8538481
OpenAlexW3206032778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.