Evidence map›Paper›PMID 34683384›Full record

ArticleMicroorganisms2021

Dietary Microencapsulated Blend of Organic Acids and Plant Essential Oils Affects Intestinal Morphology and Microbiome of Rainbow Trout (

David Huyben, Marcia Chiasson, John S Lumsden, Phuc H Pham, Mohiuddin A Kabir Chowdhury

Abstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
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  7. Article
  8. Identification and characterization ofMicrobiology spectrum · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Growth Performance and Disease Resistance againstAnimals : an open access journal from MDPI · 2023
    Article
  13. Article
  14. Effects ofInternational journal of molecular sciences · 2023
    Article
  15. Article
  16. Impact of Infection withPathogens (Basel, Switzerland) · 2023
    Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

David HuybenDepartment of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.ORCID 0000-0001-7913-851X
Marcia ChiassonOntario Aquaculture Research Centre, Office of Research, University of Guelph, Elora, ON N0B 1S0, Canada.
John S LumsdenDepartment of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Phuc H PhamDepartment of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Mohiuddin A Kabir ChowdhuryJefo Nutrition Inc., Saint-Hyacinthe, QC J2S 7B6, Canada.ORCID 0000-0002-4981-1969

Funding

Jefo Nutrition Inc. 4503
6 · The paper itself

Abstract

A study was conducted on 500 juvenile rainbow trout (122 ± 4 g) fed either a control diet or a treatment diet containing 300 mg/kg of a microencapsulated blend of organic acids and essential oils to elucidate effects on intestinal morphology and microbiome. Proximal intestinal villi length was significantly increased in fish fed the treatment diet. Despite no differences in gut inflammation scores, edema, lamina propria inflammation and apoptosis were completely absent in the distal intestine of fish fed the treatment diet. Next-generation sequencing of the 16S rDNA showed no differences in alpha and beta diversity, and gut bacteria were mainly composed of Firmicutes, Bacteroidetes and Proteobacteria. On the genus level, LefSe analysis of indicator OTUs showed

Indexed as

16S rDNA sequencingaquaculturefeed additivegut inflammationintestinal healthviable plate counts

Identifiers

PMID34683384
PMCPMC8537560

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.