Evidence map›Paper›PMID 34683376›Full record

ArticleMicroorganisms2021

Bacterial Membrane-Derived Vesicles Attenuate Vancomycin Activity against Methicillin-Resistant

Monika Kumaraswamy, Kamilla Wiull, Bishnu Joshi, George Sakoulas, Armin Kousha, Gustav Vaaje-Kolstad, Mona Johannessen, Kristin Hegstad, Victor Nizet, Fatemeh Askarian

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Loaded delta-hemolysin shapes the properties ofFrontiers in microbiology · 2023
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Monika KumaraswamyInfectious Diseases Section, VA San Diego Healthcare System, San Diego, CA 92161, USA.ORCID 0000-0002-3867-4268
Kamilla WiullFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, 1433 Ås, Norway.
Bishnu JoshiResearch Group for Host-Microbe Interactions, UiT-The Arctic University of Norway, 9037 Tromsø, Norway.ORCID 0000-0003-3841-0796
George SakoulasDepartment of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
Armin KoushaDepartment of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
Gustav Vaaje-KolstadFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, 1433 Ås, Norway.ORCID 0000-0002-3077-8003
Mona JohannessenResearch Group for Host-Microbe Interactions, UiT-The Arctic University of Norway, 9037 Tromsø, Norway.
Kristin HegstadResearch Group for Host-Microbe Interactions, UiT-The Arctic University of Norway, 9037 Tromsø, Norway.ORCID 0000-0002-1314-0497
Victor NizetCollaborative to Halt Antibiotic Resistant Microbes (CHARM), University of California San Diego, La Jolla, CA 92093, USA.
Fatemeh AskarianResearch Group for Host-Microbe Interactions, UiT-The Arctic University of Norway, 9037 Tromsø, Norway.
University of California San Diego · USNorwegian University of Life Sciences · NOUiT The Arctic University of Norway · NOUniversity Hospital of North Norway · NO

Funding

UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
Systems Biology Approach to Redefine Susceptibility Testing and Treatment of MDR Pathogens in the Context of Host ImmunityU01AI124316 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PALSSON, BERNHARD O · 2016 to 2020
$10.2M
Surprising Efficacy of Discounted Antibiotics vs. MDR Gram-Negative Pathogens Occurring Through Innate Immune SensitizationR01AI145310 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMARASWAMY, MONIKA, NIZET, VICTOR · 2020 to 2023
$1.9M
NCATS NIH HHS KL2 TR001444NIAID NIH HHS R01 AI145310NIAID NIH HHS U01 AI124316NIH HHS 1KL2TR001444NIH HHS 1R01AI145310-01A1NIH HHS 1U01AI124316-01NIH HHS U54-HD090259
6 · The paper itself

Abstract

Methicillin-resistant

Indexed as

membrane vesiclesmethicillin-resistant Staphylococcus aureusvancomycin

Identifiers

PMID34683376
PMCPMC8539228
OpenAlexW3203846877

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.