Evidence map›Paper›PMID 34683362›Full record

ReviewMicroorganisms2021

Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives.

Natalia Vaou, Elisavet Stavropoulou, Chrysa Voidarou, Christina Tsigalou, Eugenia Bezirtzoglou

Abstract readReview
In one paragraph

Review in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 324 papers.

0numbers the graph read from it
0cells of the map it votes in
324citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

324 citing papers in PubMed.

  1. Veterinary and animal science · 2026
    Article
  2. Article
  3. Article
  4. A comprehensive review ofBiochemistry and biophysics reports · 2026
    Review
  5. UropathogenicAntibiotics (Basel, Switzerland) · 2026
    Review
  6. Article
  7. Callus Induction inPlants (Basel, Switzerland) · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Prevention and Treatment ofPathogens (Basel, Switzerland) · 2026
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Plants (Basel, Switzerland) · 2026
    Review
  18. Article
  19. Article
  20. Article

264 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Natalia VaouLaboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, Greece.
Elisavet StavropoulouDepartment of Infectious Diseases, Centre Hospitalier Universitaire Vaudois (CHUV), Rue du Bugnon, 1011 Lausanne, Switzerland.
Chrysa VoidarouDepartment of Agriculture, University of Ioannina, 47132 Arta, Greece.
Christina TsigalouLaboratory of Microbiology, Department of Medicine, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, Greece.ORCID 0000-0002-7869-6824
Eugenia BezirtzoglouLaboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, Greece.ORCID 0000-0002-2010-2544

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing incidence of drug- resistant pathogens raises an urgent need to identify and isolate new bioactive compounds from medicinal plants using standardized modern analytical procedures. Medicinal plant-derived compounds could provide novel straightforward approaches against pathogenic bacteria. This review explores the antimicrobial activity of plant-derived components, their possible mechanisms of action, as well as their chemical potential. The focus is put on the current challenges and future perspectives surrounding medicinal plants antimicrobial activity. There are some inherent challenges regarding medicinal plant extracts and their antimicrobial efficacy. Appropriate and optimized extraction methodology plant species dependent leads to upgraded and selective extracted compounds. Antimicrobial susceptibility tests for the determination of the antimicrobial activity of plant extracts may show variations in obtained results. Moreover, there are several difficulties and problems that need to be overcome for the development of new antimicrobials from plant extracts, while efforts have been made to enhance the antimicrobial activity of chemical compounds. Research on the mechanisms of action, interplay with other substances, and the pharmacokinetic and/or pharmacodynamic profile of the medicinal plant extracts should be given high priority to characterize them as potential antimicrobial agents.

Indexed as

antimicrobial activitybioactive compoundschallengesfuture perspectivesmedicinal plantsnew antimicrobials

Identifiers

PMID34683362
PMCPMC8541629

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.