Evidence map›Paper›PMID 34683357›Full record

ArticleMicroorganisms2021

Immunity Profiling of COVID-19 Infection, Dynamic Variations of Lymphocyte Subsets, a Comparative Analysis on Four Different Groups.

Mario Giosuè Balzanelli, Pietro Distratis, Gianna Dipalma, Luigi Vimercati, Orazio Catucci, Felice Amatulli, Angelo Cefalo, Rita Lazzaro, Davide Palazzo, Sergey Khachatur Aityan and 15 more

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 6 institutions in 3 countries.

Mario Giosuè BalzanelliSET-118, Department of Pre-Hospital and Emergency, SG Giuseppe Moscati Hospital, 74100 Taranto, Italy.
Pietro DistratisSET-118, Department of Pre-Hospital and Emergency, SG Giuseppe Moscati Hospital, 74100 Taranto, Italy.
Gianna DipalmaDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-5947-8987
Luigi VimercatiDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-4072-2871
Orazio CatucciSET-118, Department of Pre-Hospital and Emergency, SG Giuseppe Moscati Hospital, 74100 Taranto, Italy.
Felice AmatulliSET-118, Department of Pre-Hospital and Emergency, SG Giuseppe Moscati Hospital, 74100 Taranto, Italy.
Angelo CefaloSET-118, Department of Pre-Hospital and Emergency, SG Giuseppe Moscati Hospital, 74100 Taranto, Italy.
Rita LazzaroSET-118, Department of Pre-Hospital and Emergency, SG Giuseppe Moscati Hospital, 74100 Taranto, Italy.ORCID 0000-0002-2670-8811
Davide PalazzoSET-118, Department of Pre-Hospital and Emergency, SG Giuseppe Moscati Hospital, 74100 Taranto, Italy.
Sergey Khachatur AityanDirector Multidisciplinary Research Center, Lincoln University, Oakland, CA 94612, USA.
Giancarla PricoloDepartment of Hematology, SS. Annunziata, 74100 Taranto, Italy.
Antonella PrudenzanoDepartment of Hematology, SS. Annunziata, 74100 Taranto, Italy.
Patrizia D'ErricoDepartment of Hematology, SS. Annunziata, 74100 Taranto, Italy.
Rita LaforgiaDepartment of Emergency and Organ Transplantation, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-3580-4976
Angela PezzollaDepartment of Emergency and Organ Transplantation, University of Bari "Aldo Moro", 70124 Bari, Italy.
Diego TomassoneFoundation of Physics Research Center, 87053 Celico, Italy.
Alessio Danilo InchingoloDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-6366-1039
Van Hung PhamDepartment of Microbiology, "Phan Chau Trinh" University of Medicine and Nam-Khoa Biotek, Ho Chi Minh 50000, Vietnam.
Donatello IacoboneSET-118, Department of Pre-Hospital and Emergency, BAT, 76121 Barletta, Italy.
Giuseppe Mancusi MateriAnesthesia and Intensive Care Unit, Department of Emergency, University of Bari "Aldo Moro", 70124 Bari, Italy.
Antonio ScaranoDepartment of Innovative Technologies in Medicine and Dentistry, University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-1374-6146
Felice LorussoDepartment of Innovative Technologies in Medicine and Dentistry, University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-2660-9231
Francesco InchingoloDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-3797-5883
Kieu Cao Diem NguyenDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Ciro Gargiulo IsaccoSET-118, Department of Pre-Hospital and Emergency, SG Giuseppe Moscati Hospital, 74100 Taranto, Italy.
University of Bari Aldo Moro · ITAzienda Ospedaliera S.Giuseppe Moscati · ITOspedale SS. Annunziata · ITUniversity of Chieti-Pescara · ITUniversity of Khanh Hoa · VNLincoln University - California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA novel coronavirus (SARS-CoV-2)-induced pneumonia (COVID-19) emerged in December 2019 in China, spreading worldwide. The aim of the present investigation was to evaluate the immunological response and the clinical subset of peripheral lymphocyte subset alteration in COVID-19 infection.

methodsthe study was conducted on four different clinical groups (

resultsLymphocytes (%) cells showed a decline in COVID-19 patients. The subsets showed a significant association with the inflammatory status in COVID-19, especially with regard to increased neutrophils, T-killer, T-active, T-suppressor, and T-CD8+CD38+ in individuals belong to the either COVID-19 and Covid-like NP group.

conclusionsPeripheral lymphocyte subset alteration was associated with the clinical characteristics and progression of COVID-19. The level of sub-set cells T-lymphocytes (either high or low) and B-lymphocytes could be used as an independent predictor for COVID-19 severity and treatment efficacy.

Indexed as

broncho-alveolar lavage fluid (BALF)cellular immunitycoronavirushumoral responseSARS-CoV-2

Identifiers

PMID34683357
PMCPMC8540733
OpenAlexW3201859240

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.