ReviewMicroorganisms2021
Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System.
Review in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 63 citations in OpenAlex.
- Article
- Vancomycin resistance in gram-positive infections: evolutionary strategies of survival.Archives of microbiology · 2026Review
- Vancomycin variable Enterococci in the Netherlands (2018-2023) and the mechanism of resistance induction.PloS one · 2026Article
- Chemoproteomic profiling of adaptive ATP-binding protein activity inFEMS microbes · 2026Article
- Pubescine as a Novel Antibacterial Agent Against Vancomycin-resistant Enterococcus: Growth Inhibition, Antibiotic Synergy, and Anti-biofilm Activity.Current pharmaceutical biotechnology · 2026Article
- A nitric oxide-sensing two-component system regulates a range of infection-related phenotypes inmSphere · 2025Article
- Genomic Epidemiology of Vancomycin-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Transposon-directed insertion-site sequencing (TraDIS) analysis ofMicrobiology spectrum · 2025Article
- Selective expansion of gut antibiotic resistome and underlying pathways involved in type 1 diabetes.iMetaOmics · 2025Article
- Cockroach Microbiome Disrupts Indoor Environmental Microbial Ecology with Potential Public Health Implications.Environment & health (Washington, D.C.) · 2025Article
- Genome-wide analysis ofJournal of bacteriology · 2025Article
- Article
- Anti-Biofilm Effects of Z102-E ofFoods (Basel, Switzerland) · 2024Article
- Phylogenetic Analysis of the Genes in D-Ala-D-Lactate Synthesizing Glycopeptide Resistance Operons: The Different Origins of Functional and Regulatory Genes.Antibiotics (Basel, Switzerland) · 2024Article
- Histidine kinase-mediated cross-regulation of the vancomycin-resistance operon in Clostridioides difficile.Molecular microbiology · 2024Article
- Evaluation of Antimicrobial Resistancein Clinical Isolates ofMedicina (Kaunas, Lithuania) · 2024Article
- Diazirine Photoprobes for the Identification of Vancomycin-Binding Proteins.ACS bio & med chem Au · 2024Article
- Antimicrobial and anti-biofilm activity of a thiazolidinone derivative againstMicrobiology spectrum · 2024Article
- Article
- Integration of vanHAX downstream of a ribosomal RNA operon restores vancomycin resistance in a susceptible Enterococcus faecium strain.npj antimicrobials and resistance · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Vancomycin-resistant enterococci (VRE) are a serious threat to human health, with few treatment options being available. New therapeutics are urgently needed to relieve the health and economic burdens presented by VRE. A potential target for new therapeutics is the VanRS two-component system, which regulates the expression of vancomycin resistance in VRE. VanS is a sensor histidine kinase that detects vancomycin and in turn activates VanR; VanR is a response regulator that, when activated, directs expression of vancomycin-resistance genes. This review of VanRS examines how the expression of vancomycin resistance is regulated, and provides an update on one of the field's most pressing questions: How does VanS sense vancomycin?
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.