Evidence map›Paper›PMID 34683316›Full record

ArticleMicromachines2021

Modeling Brownian Microparticle Trajectories in Lab-on-a-Chip Devices with Time Varying Dielectrophoretic or Optical Forces.

Mohammad Asif Zaman, Mo Wu, Punnag Padhy, Michael A Jensen, Lambertus Hesselink, Ronald W Davis

Open access · goldAbstract read
In one paragraph

Article in Micromachines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Controlled Transport of Individual Microparticles Using Dielectrophoresis.Langmuir : the ACS journal of surfaces and colloids · 2023
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mohammad Asif ZamanDepartment of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-7295-2102
Mo WuDepartment of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-8841-3392
Punnag PadhyDepartment of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-3967-5377
Michael A JensenStanford Genome Technology Center, Department of Biochemistry, Stanford University, Palo Alto, CA 94304, USA.
Lambertus HesselinkDepartment of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.
Ronald W DavisStanford Genome Technology Center, Department of Biochemistry, Stanford University, Palo Alto, CA 94304, USA.
Stanford University · USPalo Alto University · US

Funding

A nanophotonic approach to building DNA using enzymatic synthesisR01GM138716 · NIGMS · STANFORD UNIVERSITY · PI DAVIS, RONALD WAYNE · 2020 to 2023
$1.8M
Ultra high-throughput DNA synthesis via nano-optical conveyer beltsR21HG009758 · NHGRI · STANFORD UNIVERSITY · PI DAVIS, RONALD WAYNE · 2017 to 2018
$605k
NHGRI NIH HHS 5R21HG009758NIGMS NIH HHS R01 GM138716NIGMS NIH HHS R01GM138716
6 · The paper itself

Abstract

Lab-on-a-chip (LOC) devices capable of manipulating micro/nano-sized samples have spurred advances in biotechnology and chemistry. Designing and analyzing new and more advanced LOCs require accurate modeling and simulation of sample/particle dynamics inside such devices. In this work, we present a generalized computational physics model to simulate particle/sample trajectories under the influence of dielectrophoretic or optical forces inside LOC devices. The model takes into account time varying applied forces, Brownian motion, fluid flow, collision mechanics, and hindered diffusion caused by hydrodynamic interactions. We develop a numerical solver incorporating the aforementioned physics and use it to simulate two example cases: first, an optical trapping experiment, and second, a dielectrophoretic cell sorter device. In both cases, the numerical results are found to be consistent with experimental observations, thus proving the generality of the model. The numerical solver can simulate time evolution of the positions and velocities of an arbitrarily large number of particles simultaneously. This allows us to characterize and optimize a wide range of LOCs. The developed numerical solver is made freely available through a GitHub repository so that researchers can use it to develop and simulate new designs.

Indexed as

Brownian dynamicsdielectrophoresisLab-on-a-chipLangevin equationoptical trap

Identifiers

PMID34683316
PMCPMC8539052
OpenAlexW3206460360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.