Evidence map›Paper›PMID 34683180›Full record

ArticleJournal of personalized medicine2021

A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study.

Andreea Ciudin, Enzamaría Fidilio, Liliana Gutiérrez-Carrasquilla, Assumpta Caixàs, Núria Vilarrasa, Silvia Pellitero, Andreu Simó-Servat, Ramon Vilallonga, Amador Ruiz, Maricruz de la Fuente and 7 more

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02405949 completednot on this map

Genetic susceptibility factor as a predictor of type 2 diabetes remission and weight loss after bariatric surgery: how to identify the patients in which bariatric surgery will fail?

TypeobservationalSponsorHospital Universitari Vall d'Hebron Research InstituteRan2013 to 2015Enrolled100ConditionsCase-control StudyArmsGenetic test
NCT06226194 recruitingnot on this mapstarted 2024, after this paper: background citation

Genetic Susceptibility to Predict Weight Loss After Bariatric Surgery

Typeobservational_patient_registrySponsorInstitut de Recerca Biomèdica de LleidaRan2024 to 2028Enrolled6,966ConditionsBariatric Surgery Candidate, Obesity, Morbid, Genetic Predisposition, Metabolic Syndrome
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

Andreea CiudinEndocrinology and Nutrition Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.ORCID 0000-0001-5622-0203
Enzamaría FidilioEndocrinology and Nutrition Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.
Liliana Gutiérrez-CarrasquillaEndocrinology and Nutrition Department, Hospital Universitari Arnau de Vilanova, Obesity, Diabetes and Metabolism Research Group (ODIM), Institut de Recerca Biomèdica de Lleida (IRBLleida), Universitat de Lleida, 25198 Lleida, Spain.
Assumpta CaixàsEndocrinology and Nutrition Department, Hospital Universitari Parc Tauli, Medicine Department, Universitat Autònoma de Barcelona, Institut d'Investigació i Innovació Parc Taulí, 08208 Sabadell, Spain.ORCID 0000-0001-8472-9189
Núria VilarrasaCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
Silvia PelliteroEndocrine and Nutrition Department, Germans Trias i Pujol University Hospital, Germans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Spain.
Andreu Simó-ServatDepartment of Endocrinology, Diabetes and Nutrition, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
Ramon VilallongaEndocrine, Metabolic and Bariatric Unit, Department of General and Digestive Surgery, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Center of Excellence for the EAC-BS, 08035 Barcelona, Spain.
Amador RuizEndocrine, Metabolic and Bariatric Unit, Department of General and Digestive Surgery, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Center of Excellence for the EAC-BS, 08035 Barcelona, Spain.ORCID 0000-0002-0485-8536
Maricruz de la FuenteGeneral and Digestive Surgery Department, Hospital Universitari Arnau de Vilanova, Institute de Recerca Biomèdica de Lleida, 25198 Lleida, Spain.
Alexis LunaSurgery Department, Esofago-Gastric Surgery Section, Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí, 08208 Sabadell, Spain.
Enric SánchezEndocrinology and Nutrition Department, Hospital Universitari Arnau de Vilanova, Obesity, Diabetes and Metabolism Research Group (ODIM), Institut de Recerca Biomèdica de Lleida (IRBLleida), Universitat de Lleida, 25198 Lleida, Spain.ORCID 0000-0001-7345-1601
Mercedes RiglaEndocrinology and Nutrition Department, Hospital Universitari Parc Tauli, Medicine Department, Universitat Autònoma de Barcelona, Institut d'Investigació i Innovació Parc Taulí, 08208 Sabadell, Spain.
Cristina HernándezEndocrinology and Nutrition Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.ORCID 0000-0002-3109-1721
Eduardo SalasScientific Department, Gendiag, 08028 Barcelona, Spain.
Rafael SimóEndocrinology and Nutrition Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.ORCID 0000-0003-0475-3096
Albert LecubeCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.ORCID 0000-0001-9684-0183
Universitat Autònoma de Barcelona · ESUniversitat de Lleida · ESBellvitge University Hospital · ESHospital Universitari Arnau de Vilanova · ESInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol · ESInstitute of Research and Innovation Parc Tauli · ESInstituto de Salud Carlos III · ES

Funding

Instituto de Salud Carlos III PI18/00964Menarini (Spain)Pla Estratègic de Recerca i Innovació en Salut (PERIS) SLT002/16/00497
6 · The paper itself

Abstract

Around 30% of the patients that undergo bariatric surgery (BS) do not reach an appropriate weight loss. The OBEGEN study aimed to assess the added value of genetic testing to clinical variables in predicting weight loss after BS. A multicenter, retrospective, longitudinal, and observational study including 416 patients who underwent BS was conducted (Clinical.Trials.gov- NCT02405949). 50 single nucleotide polymorphisms (SNPs) from 39 genes were examined. Receiver Operating Characteristic (ROC) curve analysis were used to calculate sensitivity and specificity. Satisfactory response to BS was defined as at nadir excess weight loss >50%. A good predictive model of response [area under ROC of 0.845 (95% CI 0.805-0.880),

Indexed as

bariatric surgerygeneticsobesitypolygenic riskweight loss

Identifiers

PMID34683180
PMCPMC8537695
OpenAlexW3206304956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.