Evidence map›Paper›PMID 34683167›Full record

ReviewJournal of personalized medicine2021

Molecular and Genetic Immune Biomarkers of Primary and Immune-Therapy Induced Hypophysitis: From Laboratories to the Clinical Practice.

Sabrina Chiloiro, Filippo Russo, Tommaso Tartaglione, Ettore Domenico Capoluongo

Open access · goldAbstract readReview
In one paragraph

Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Sabrina ChiloiroDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.
Filippo RussoDepartment of Molecular Medicine and Medical Biotechnology, Federico II University-CEINGE, 80126 Naples, Italy.ORCID 0000-0001-8128-9878
Tommaso TartaglioneDepartment of Radiological and Haematological Sciences, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.
Ettore Domenico CapoluongoAzienda Ospedaliera per L'Emergenza, Cannizzaro, 95126 Catania, Italy.ORCID 0000-0002-5647-4059
Università Cattolica del Sacro Cuore · ITFederico II University Hospital · ITOspedale Cannizzaro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypophysitis is a rare and potentially life-threatening disease, characterized by an elevated risk of complications, such as the occurrence of acute central hypoadrenalism, persistent hypopituitarism, or the extension of the inflammatory process to the neighboring neurological structures. In recent years, a large number of cases has been described. The diagnosis of hypophysitis is complex because it is based on clinical and radiological criteria. Due to this, the integration of molecular and genetic biomarkers can help physicians in the diagnosis of hypophysitis and play a role in predicting disease outcome. In this paper, we review current knowledge about molecular and genetic biomarkers of hypophysitis with the aim of suggesting a possible integration of these biomarkers in clinical practice.

Indexed as

anti-pituitary antibodiesCTLA-4cytokinesdiabetes insipidusHLAhypoadrenalismhypopituitarismimmune-check point inhibitorsipilimumabMHCnivolumabPD-1

Identifiers

PMID34683167
PMCPMC8537090
OpenAlexW3206469154

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.