Evidence map›Paper›PMID 34683143›Full record

ArticleJournal of personalized medicine2021

Impact of Tacrolimus Daily Dose Limitation in Renal Transplant Recipients Expressing CYP3A5: A Retrospective Study.

Rémi Lenain, Mehdi Maanaoui, Aghilès Hamroun, Romain Larrue, Cynthia Van Der Hauwaert, Jean-Baptiste Gibier, Viviane Gnemmi, Sébastien Gomis, Myriam Labalette, Franck Broly and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Rémi LenainCHU Lille, Service de Néphrologie, F-59000 Lille, France.
Mehdi MaanaouiCHU Lille, Service de Néphrologie, F-59000 Lille, France.
Aghilès HamrounCHU Lille, Service de Néphrologie, F-59000 Lille, France.
Romain LarrueUMR9020-U1277-CANTHER-Cancer Heterogeneity, Plasticity and Resistance to Therapies, University Lille, CNRS, Inserm, CHU Lille, F-59000 Lille, France.
Cynthia Van Der HauwaertUMR9020-U1277-CANTHER-Cancer Heterogeneity, Plasticity and Resistance to Therapies, University Lille, CNRS, Inserm, CHU Lille, F-59000 Lille, France.
Jean-Baptiste GibierCHU Lille, Service d'Anatomo-Pathologie, F-59000 Lille, France.ORCID 0000-0002-1194-5590
Viviane GnemmiCHU Lille, Service d'Anatomo-Pathologie, F-59000 Lille, France.
Sébastien GomisCHU Lille, Service de Néphrologie, F-59000 Lille, France.
Myriam LabaletteCHU de Lille, Institut D'Immunologie-HLA, F-59000 Lille, France.
Franck BrolyCHU Lille, Service de Toxicologie et Génopathies, F-59000 Lille, France.
Benjamin HennartCHU Lille, Service de Toxicologie et Génopathies, F-59000 Lille, France.
Nicolas PottierUMR9020-U1277-CANTHER-Cancer Heterogeneity, Plasticity and Resistance to Therapies, University Lille, CNRS, Inserm, CHU Lille, F-59000 Lille, France.
Marc HazzanCHU Lille, Service de Néphrologie, F-59000 Lille, France.
Christelle CauffiezUMR9020-U1277-CANTHER-Cancer Heterogeneity, Plasticity and Resistance to Therapies, University Lille, CNRS, Inserm, CHU Lille, F-59000 Lille, France.
François GlowackiCHU Lille, Service de Néphrologie, F-59000 Lille, France.
Centre Hospitalier Universitaire de Lille · FRCentre National de la Recherche Scientifique · FRUniversité de Lille · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pharmacokinetic variability of tacrolimus can be partly explained by CYP3A5 activity. Our objective was to evaluate a tacrolimus sparing policy on renal graft outcome according to

Indexed as

pharmacogeneticspolymorphismrenal transplantationtacrolimustherapeutic drug monitoring

Identifiers

PMID34683143
PMCPMC8539387
OpenAlexW3204100208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.