Evidence map›Paper›PMID 34682876›Full record

ArticleJournal of clinical medicine2021

Flexible Magnifying Endoscopy with Narrow Band Imaging for Diagnosing Uterine Cervical Neoplasms: A Multicenter Prospective Study.

Hideki Kobara, Kunihisa Uchita, Noriya Uedo, Jun Kunikata, Kenji Yorita, Naoya Tada, Noriko Nishiyama, Yuriko Shigehisa, Chihiro Kuroiwa, Noriko Matsuura and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Transvaginal flexible endoscopy for bleeding arteriovenous malformation hemostasis near a vesico-rectovaginal fistula.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2025
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Hideki KobaraDepartment of Gastroenterology and Neurology, Faculty of Medicine, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan.ORCID 0000-0002-8508-827X
Kunihisa UchitaDepartment of Gastroenterology, Kochi Red Cross Hospital, 2-13-51 Shinhonmachi, Kochi 780-8562, Japan.ORCID 0000-0003-3404-7280
Noriya UedoDepartment of Gastrointestinal Oncology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka 541-8567, Japan.
Jun KunikataDepartment of Clinical Research Support Center, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan.
Kenji YoritaDepartment of Diagnostic Pathology, Kochi Red Cross Hospital, 2-13-51 Shinhonmachi, Kochi 780-8562, Japan.
Naoya TadaDepartment of Gastroenterology and Neurology, Faculty of Medicine, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan.
Noriko NishiyamaDepartment of Gastroenterology and Neurology, Faculty of Medicine, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan.
Yuriko ShigehisaDepartment of Gastroenterology, Kochi Red Cross Hospital, 2-13-51 Shinhonmachi, Kochi 780-8562, Japan.
Chihiro KuroiwaDepartment of Gastroenterology, Kochi Red Cross Hospital, 2-13-51 Shinhonmachi, Kochi 780-8562, Japan.
Noriko MatsuuraDepartment of Gastrointestinal Oncology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka 541-8567, Japan.
Yohei TakahashiDepartment of Gynecology, Kochi Red Cross Hospital, Kochi, 2-13-51 Shinhonmachi, Kochi 780-8562, Japan.
Yuka KaiDepartment of Gynecology, Kochi Red Cross Hospital, Kochi, 2-13-51 Shinhonmachi, Kochi 780-8562, Japan.
Uiko HanaokaDepartment of Perinatology and Gynecology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan.
Yumiko KiyoharaDepartment of Gynecology, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka 541-8567, Japan.ORCID 0000-0001-9818-2233
Shoji KamiuraDepartment of Gynecology, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka 541-8567, Japan.ORCID 0000-0002-5723-8891
Kenji KanenishiDepartment of Perinatology and Gynecology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan.
Tsutomu MasakiDepartment of Gastroenterology and Neurology, Faculty of Medicine, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan.
Koki HiranoDepartment of Gynecology, Kochi Red Cross Hospital, Kochi, 2-13-51 Shinhonmachi, Kochi 780-8562, Japan.
Japanese Red Cross Kochi Hospital · JPKagawa University · JPOsaka International Cancer Institute · JPOsaka Hospital · JP

Funding

Japan Society for the Promotion of Science 17K15775
6 · The paper itself

Abstract

We aimed to investigate the diagnostic ability of magnifying endoscopy with narrow band imaging (ME-NBI) for cervical intraepithelial neoplasia grade 2 or worse (CIN2+). This was a multicenter prospective study. Eligible patients had positive Pap smear results or follow-up high-grade cytology or CIN3 diagnosed in referring hospitals. Patients underwent ME-NBI by a gastrointestinal endoscopist, followed by colposcopy by a gynecologist. One lesion with the worst finding was considered the main lesion. Punch biopsies were collected from all indicated areas and one normal area. The reference standard was the highest histological grade among all biopsy specimens. The primary endpoint was the detection rate of patients with CIN2+ in the main lesion. The secondary endpoints were diagnostic ability for CIN2+ lesions and patients' acceptability. We enrolled 88 patients. The detection rate of ME-NBI for patients with CIN2+ was 79% (95% CI: 66-88%;

Indexed as

cervical intraepithelial neoplasiacolposcopyendoscopyuterine cervical neoplasms

Identifiers

PMID34682876
PMCPMC8536977
OpenAlexW3205381970

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.