Evidence map›Paper›PMID 34682758›Full record

ArticleJournal of clinical medicine2021

Single-Nucleotide Polymorphisms in MICA and MICB Genes Could Play a Role in the Outcome in AML Patients after HSCT.

Alena Machuldova, Lucie Houdova, Katerina Kratochvilova, Martin Leba, Pavel Jindra, Pavel Ostasov, Diana Maceckova, Robin Klieber, Hana Gmucova, Jiri Sramek and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Alena MachuldovaLaboratory of Tumor Biology and Immunotherapy, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech Republic.ORCID 0000-0001-8904-6520
Lucie HoudovaNTIS, Faculty of Applied Sciences, University of West Bohemia, 301 00 Pilsen, Czech Republic.
Katerina KratochvilovaNTIS, Faculty of Applied Sciences, University of West Bohemia, 301 00 Pilsen, Czech Republic.
Martin LebaNTIS, Faculty of Applied Sciences, University of West Bohemia, 301 00 Pilsen, Czech Republic.
Pavel JindraDepartment of Haematology and Oncology, University Hospital Pilsen, 304 60 Pilsen, Czech Republic.ORCID 0000-0002-8415-7069
Pavel OstasovLaboratory of Tumor Biology and Immunotherapy, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech Republic.ORCID 0000-0001-7168-6431
Diana MaceckovaLaboratory of Tumor Biology and Immunotherapy, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech Republic.ORCID 0000-0003-3147-5693
Robin KlieberLaboratory of Tumor Biology and Immunotherapy, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech Republic.ORCID 0000-0003-2766-8660
Hana GmucovaDepartment of Haematology and Oncology, University Hospital Pilsen, 304 60 Pilsen, Czech Republic.
Jiri SramekDepartment of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University, 301 66 Pilsen, Czech Republic.
Monika HolubovaLaboratory of Tumor Biology and Immunotherapy, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech Republic.ORCID 0000-0002-5096-9659
Charles University · CZUniversity of West Bohemia in Pilsen · CZ

Funding

Ministerstvo Zdravotnictví Ceské Republiky NV18-03-00277
6 · The paper itself

Abstract

NKG2D and its ligands, MICA and MICB, are known as the key regulators of NK cells. NK cells are the first reconstituted cells after the allogeneic hematopoietic stem cell transplantation (HSCT); therefore, it is crucial to understand their role in HSCT outcome. In the presented study, we investigated the single amino acid changes across the exons 2-4 of MICA and MICB genes, and point mutations within the NKG2D gene, which defines the type of NKG2D haploblock (HNK/LNK) in the donors (

Indexed as

allogeneic hematopoietic cell transplantationgraft-versus-host diseasegraft-versus-tumor effectMICAMICBNK cellsNKG2D

Identifiers

PMID34682758
PMCPMC8537017
OpenAlexW3206502108

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.