Evidence map›Paper›PMID 34682575›Full record

ArticleInternational journal of environmental research and public health2021

Association of COMT Polymorphisms with Multiple Physical Activity-Related Injuries among University Students in China.

Shangmin Chen, Weicong Cai, Shiwei Duan, Lijie Gao, Wenda Yang, Yang Gao, Cunxian Jia, Hongjuan Zhang, Liping Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Shangmin ChenInjury Prevention Research Center, Shantou University Medical College, Shantou 515041, China.
Weicong CaiInjury Prevention Research Center, Shantou University Medical College, Shantou 515041, China.ORCID 0000-0002-1597-4313
Shiwei DuanMedical Genetics Center, School of Medicine, Ningbo University, Ningbo 315211, China.
Lijie GaoDepartment of Epidemiology, Shandong University School of Public Health, Jinan 250012, China.
Wenda YangInjury Prevention Research Center, Shantou University Medical College, Shantou 515041, China.
Yang GaoDepartment of Sport and Physical Education, Hong Kong Baptist University, Kowloon Tong, Hong Kong 999077, China.ORCID 0000-0003-0439-4804
Cunxian JiaDepartment of Epidemiology, Shandong University School of Public Health, Jinan 250012, China.ORCID 0000-0002-2651-147X
Hongjuan ZhangSchool of Physical Education, Shanxi Normal University, Linfen 041000, China.
Liping LiInjury Prevention Research Center, Shantou University Medical College, Shantou 515041, China.ORCID 0000-0003-3306-779X
Shantou University · CNShandong University · CNHong Kong Baptist University · HKNingbo University · CNShanxi Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The catechol-O-methyltransferase (COMT) is a candidate gene to provide promising evidence of psychiatric disorders, but there is a knowledge gap between the genetic factor and multiple physical activity-related injuries (PARIs). The aim of this study was to explore the contribution of COMT to the risk of PARIs among university students in the Chinese Han population. We can further search for the intrinsic risk factors for the occurrence of multiple physical activity injuries and provide a scientific basis for early screening and precise intervention for the high-risk group of college students with multiple PARIs. A 1:1 matched case-control study of 61 PARIs cases and 61 healthy controls were carried out. DNA samples of the participants were isolated from saliva and genotyped on eight SNPs of the COMT gene (rs9265, rs4680, rs6269, rs4818, rs4633, rs165655, rs165656, and rs165722) using the MALDI-TOF MS method. We found that rs6269 and rs4818 were significantly associated with PARIs, and rs6269-GG and rs4818-GG contributed to the reduced risk of PARIs. Further haplotype analysis showed a four-marker C-G-C-G haplotype (rs165722-rs6269-rs4633-rs4818) acted with a protective role in the development of PARIs (

Indexed as

Catechol O-MethyltransferaseUniversitiesCase-Control StudiesChinaExerciseGenotypeHaplotypesHumansPolymorphism, Single NucleotideStudentsCatechol O-MethyltransferaseCOMT protein, humanCatechol-O-methyltransferaseCOMTphysical activitypolymorphismsSNPssports injuries

Identifiers

PMID34682575
PMCPMC8535648
OpenAlexW3207692784

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.