Evidence map›Paper›PMID 34681944›Full record

ReviewInternational journal of molecular sciences2021

Alveolar Regeneration in COVID-19 Patients: A Network Perspective.

Shishir K Gupta, Mugdha Srivastava, Rashmi Minocha, Aman Akash, Seema Dangwal, Thomas Dandekar

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Shishir K GuptaFunctional Genomics & Systems Biology Group, Department of Bioinformatics, Biocenter, Am Hubland, University of Wuerzburg, D-97074 Wuerzburg, Germany.ORCID 0000-0002-2335-1597
Mugdha SrivastavaFunctional Genomics & Systems Biology Group, Department of Bioinformatics, Biocenter, Am Hubland, University of Wuerzburg, D-97074 Wuerzburg, Germany.ORCID 0000-0002-7449-9911
Rashmi MinochaDepartment of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
Aman AkashFunctional Genomics & Systems Biology Group, Department of Bioinformatics, Biocenter, Am Hubland, University of Wuerzburg, D-97074 Wuerzburg, Germany.
Seema DangwalStanford Cardiovascular Institute, Department of Medicine Stanford University School of Medicine, Palo Alto, CA 94305-5101, USA.
Thomas DandekarFunctional Genomics & Systems Biology Group, Department of Bioinformatics, Biocenter, Am Hubland, University of Wuerzburg, D-97074 Wuerzburg, Germany.ORCID 0000-0003-1886-7625
All India Institute of Medical Sciences · INCardiovascular Institute of the South · USEuropean Molecular Biology Laboratory · DE

Funding

Deutsche Forschungsgemeinschaft 324392634-TRR 221/INF
6 · The paper itself

Abstract

A viral infection involves entry and replication of viral nucleic acid in a host organism, subsequently leading to biochemical and structural alterations in the host cell. In the case of SARS-CoV-2 viral infection, over-activation of the host immune system may lead to lung damage. Albeit the regeneration and fibrotic repair processes being the two protective host responses, prolonged injury may lead to excessive fibrosis, a pathological state that can result in lung collapse. In this review, we discuss regeneration and fibrosis processes in response to SARS-CoV-2 and provide our viewpoint on the triggering of alveolar regeneration in coronavirus disease 2019 (COVID-19) patients.

Indexed as

RegenerationCOVID-19EpigenomicsFibrosisHumansImmune SystemLungMicroRNAsSARS-CoV-2Signal TransductionMicroRNAsalveolar fibrosisalveolar regenerationCOVID-19network biologySARS-CoV-2signaling pathway

Identifiers

PMID34681944
PMCPMC8538208
OpenAlexW3206402262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.