Evidence map›Paper›PMID 34681943›Full record

ArticleInternational journal of molecular sciences2021

Sodium Butyrate Enhances Curcuminoids Permeability through the Blood-Brain Barrier, Restores Wnt/β-Catenin Pathway Antagonists Gene Expression and Reduces the Viability of Glioblastoma Cells.

Aleksandra Majchrzak-Celińska, Robert Kleszcz, Anna Stasiłowicz-Krzemień, Judyta Cielecka-Piontek

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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  20. Curcumin 3.0-Therapeutic and Diagnostic Potential in Cancer and Beyond.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Aleksandra Majchrzak-CelińskaDepartment of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4 Święcicki Str., 60-781 Poznań, Poland.ORCID 0000-0002-2872-8875
Robert KleszczDepartment of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4 Święcicki Str., 60-781 Poznań, Poland.ORCID 0000-0002-6607-7436
Anna Stasiłowicz-KrzemieńDepartment of Pharmacognosy, Poznan University of Medical Sciences, 4 Święcicki Str., 60-781 Poznań, Poland.ORCID 0000-0001-5211-661X
Judyta Cielecka-PiontekDepartment of Pharmacognosy, Poznan University of Medical Sciences, 4 Święcicki Str., 60-781 Poznań, Poland.ORCID 0000-0003-0891-5419
Poznan University of Medical Sciences · PL

Funding

National Science Center 2020/37/B/NZ7/03975Poznan University of Medical Sciences 502-05-33024030-50800
6 · The paper itself

Abstract

Glioblastoma (GBM) is an extremely aggressive brain tumor awaiting novel, efficient, and minimally toxic treatment. Curcuminoids (CCM), polyphenols from

Indexed as

Apoptosisbeta CateninBlood-Brain BarrierButyric AcidCell CycleCell MovementCell ProliferationDiarylheptanoidsDrug Therapy, CombinationGene Expression Regulation, NeoplasticGlioblastomaHistamine AntagonistsHumansTumor Cells, CulturedWnt1 Proteinbeta CateninButyric AcidCTNNB1 protein, humanDiarylheptanoidsHistamine AntagonistsWnt1 ProteinWNT1 protein, humanapoptosiscell cyclecurcuminoidsDNA methylationglioblastomapermeabilityreactive oxygen speciessodium butyrate

Identifiers

PMID34681943
PMCPMC8540692
OpenAlexW3207114410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.