Evidence map›Paper›PMID 34681930›Full record

ReviewInternational journal of molecular sciences2021

Advances in Nanotechnology towards Development of Silver Nanoparticle-Based Wound-Healing Agents.

Zimkhitha B Nqakala, Nicole R S Sibuyi, Adewale O Fadaka, Mervin Meyer, Martin O Onani, Abram M Madiehe

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.

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  9. Shikonin and CoFrontiers in chemistry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zimkhitha B NqakalaOrganometallics and Nanomaterials, Department of Chemical Sciences, University of the Western Cape, Bellville 7535, South Africa.ORCID 0000-0003-1115-5748
Nicole R S SibuyiDepartment of Science and Innovation (DSI)/Mintek Nanotechnology Innovation Centre (NIC)-Biolabels Node, Department of Biotechnology, University of the Western Cape, Bellville 7535, South Africa.ORCID 0000-0001-7175-5388
Adewale O FadakaDepartment of Science and Innovation (DSI)/Mintek Nanotechnology Innovation Centre (NIC)-Biolabels Node, Department of Biotechnology, University of the Western Cape, Bellville 7535, South Africa.ORCID 0000-0002-3952-2098
Mervin MeyerDepartment of Science and Innovation (DSI)/Mintek Nanotechnology Innovation Centre (NIC)-Biolabels Node, Department of Biotechnology, University of the Western Cape, Bellville 7535, South Africa.ORCID 0000-0002-8296-4860
Martin O OnaniOrganometallics and Nanomaterials, Department of Chemical Sciences, University of the Western Cape, Bellville 7535, South Africa.ORCID 0000-0002-4735-3669
Abram M MadieheDepartment of Science and Innovation (DSI)/Mintek Nanotechnology Innovation Centre (NIC)-Biolabels Node, Department of Biotechnology, University of the Western Cape, Bellville 7535, South Africa.ORCID 0000-0002-3935-467X
Mintek · ZAUniversity of the Western Cape · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since antiquity, silver-based therapies have been used in wound healing, wound care and management of infections to provide adequate healing. These therapies are associated with certain limitations, such as toxicity, skin discolouration and bacterial resistance, which have limited their use. As a result, new and innovative wound therapies, or strategies to improve the existing therapies, are sought after. Silver nanoparticles (AgNPs) have shown the potential to circumvent the limitations associated with conventional silver-based therapies as described above. AgNPs are effective against a broad spectrum of microorganisms and are less toxic, effective at lower concentrations and produce no skin discolouration. Furthermore, AgNPs can be decorated or coupled with other healing-promoting materials to provide optimum healing. This review details the history and impact of silver-based therapies leading up to AgNPs and AgNP-based nanoformulations in wound healing. It also highlights the properties of AgNPs that aid in wound healing and that make them superior to conventional silver-based wound treatment therapies.

Indexed as

Wound HealingAnimalsHumansMetal NanoparticlesSilverSilverantimicrobial agentsnanotechnologysilver-based therapysilver nanoparticleswound healing

Identifiers

PMID34681930
PMCPMC8539597
OpenAlexW3206807589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.