Evidence map›Paper›PMID 34681906›Full record

ArticleInternational journal of molecular sciences2021

Sarcomeres Morphology and Z-Line Arrangement Disarray Induced by Ventricular Premature Contractions through the Rac2/Cofilin Pathway.

Yu-Sheng Lin, Tzu-Hao Chang, Wan-Chun Ho, Shun-Fu Chang, Yung-Lung Chen, Shih-Tai Chang, Huang-Chung Chen, Kuo-Li Pan, Mien-Cheng Chen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yu-Sheng LinDivision of Cardiology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.ORCID 0000-0001-9706-4534
Tzu-Hao ChangGraduate Institute of Biomedical Informatics, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0001-7011-3754
Wan-Chun HoDivision of Cardiology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.
Shun-Fu ChangDepartment of Medical Research and Development, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.ORCID 0000-0002-2276-7785
Yung-Lung ChenDivision of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.ORCID 0000-0001-7465-0880
Shih-Tai ChangDivision of Cardiology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.ORCID 0000-0003-1485-0893
Huang-Chung ChenDivision of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Kuo-Li PanDivision of Cardiology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.ORCID 0000-0001-5418-9724
Mien-Cheng ChenDivision of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.ORCID 0000-0002-3184-4404
Chang Gung University · TWChiayi Chang Gung Memorial Hospital · TWTaipei Medical University · TW

Funding

Chiayi Chang Gung Memorial Hospital NMRPG8F6081, NMRPG8F6082, NMRPG8F6083Ministry of Science and Technology MOST 105-2314-B-182A-101-MY3, 106-2314-B-182A-092, 107-2314-B-182A-161
6 · The paper itself

Abstract

The most common ventricular premature contractions (VPCs) originate from the right ventricular outflow tract (RVOT), but the molecular mechanisms of altered cytoskeletons of VPC-induced cardiomyopathy remain unexplored. We created a RVOT bigeminy VPC pig model (

Indexed as

Actin CytoskeletonActin Depolymerizing FactorsAnimalsArrhythmias, CardiacHeart VentriclesMaleRAC2 GTP-Binding Proteinrac GTP-Binding ProteinsSarcomeresSwineSwine, MiniatureActin Depolymerizing FactorsRAC2 GTP-Binding Proteinrac GTP-Binding Proteinsactin cytoskeleton signalingcardiomyopathyRac2/cofilinsarcomereventricular premature contraction

Identifiers

PMID34681906
PMCPMC8541677
OpenAlexW3207686042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.